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unreviewed

Choline acetyltransferase (ChAT)

1 reactions · 1 pathways

Cofactors used

Acetyl-CoA

Clinical / pharmacological. Acetylcholine synthesis; AChE is the organophosphate target

What it does, reaction by reaction

1 reactions

Other Neurotransmitter Synthesis Amino Acid & Nitrogen Metabolism · Cytosol

step 3 Irreversible/directional

Choline + acetyl-CoA -> acetylcholine + CoA-SH

Converts Choline Acetyl-CoA into Acetylcholine CoA-SH

› Notes

Hydrolysed at the synapse by acetylcholinesterase, the target of organophosphates and of anticholinesterase drugs.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    MergeRepair: An Exploratory Study on Merging Task-Specific Adapters in Code LLMs for Automated Program Repair.

    Dehghan M, Wu JJ, Fard FH, Ouni A. · 2026-09-25

    open access unreviewed
  2. 2
    Artificial intelligence-assisted design of self-assembling peptide hydrogels for neural regeneration: Principles and opportunities.

    Zhou Y, Jiang X, Zhang X, Yao X, Gao Z, Chen X, Gong L, Jie J, Yang Y, Yang P. · 2026-08-21

    open access unreviewed
  3. 3
    Engineering functional vasculatures to reconstruct sympathetic-parasympathetic circuits for bladder function after spinal cord injury.

    Weng H, Xiao L, Li T, Chang H, Xie P, Zhu L, Zhang B, Lv S, Hu Z, Dai Y, Hoi PM, Liu W, Liu J, Rong L, Ren Y,… · 2026-07-31

    open access unreviewed
  4. 4
    Combating antimicrobial resistance through multimodal data via artificial intelligence.

    Xia Q, Li J, Wu W, Wang J, Zhou Z, Wu M, Qiu M, Xu L, Ren J, Wu X. · 2026-09-20

    open access unreviewed
  5. 5
    Online health information-seeking behavior during the preoperative period among patients with pancreatic tumors and caregivers in China: A qualitative study.

    Cao J, Zhang P, Zheng L, Li L, Lu Z. · 2026-08-06

    open access unreviewed
  6. 6
    Calcium Isotopic Composition in Reindeer (Rangifer tarandus) Bones and Tooth Enamel: A Scalable Tool to Quantify Nursing Frequency in Past and Modern Populations?

    Hassler A, Lindroos EE, Yang L, Mester Z, Britton K, Bataille CP. · 2026-12-01

    open access unreviewed
  7. 7
    ROS-responsive hydrogel delivering liposomal indole-3-propionic acid promotes spinal cord injury repair by enhancing CX3CL1-CX3CR1 mediated neuron-microglia communication.

    Li L, Zhang Y, Wang Z, Li J, Han H, Zhang J, Liu C, Shang C, Shang G, Ji Y, Guo J, Xu Y, Zhang H, Jiang X, Ma… · 2026-09-17

    open access unreviewed
  8. 8
    "They can smell the 'short-termness' on you". Student learning and sense of belonging in the Arctic.

    Sæle RG, Borch KB, Borch I. · 2026-09-26

    open access unreviewed
  9. 9
    Risk factors for acromion and scapular spine fractures after reverse total shoulder arthroplasty: a time-to-event analysis.

    Kreutzer A, Baker C, Han B, Canumay S, Jamaleddine K, Brereton D. · 2026-08-17

    open access unreviewed
  10. 10
    From registration to insight: how STRONG AYA transforms registry data to enhance decision-support tools for adolescent and young adult oncology.

    Hughes NF, Hogenboom J, Carter RN, Norman LJ, Gouthamchand V, Lindner OC, Connearn E, Gomes AL, Sikora-Kopers… · 2026-09-15

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.