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unreviewed

Ceramide synthase (CerS1-6)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Sphingolipid Synthesis Lipid Metabolism · ER + Golgi

step 3 Irreversible/directional

Sphinganine + fatty acyl-CoA -> dihydroceramide + CoA-SH

Converts Sphinganine Fatty acyl-CoA into Dihydroceramide CoA-SH

› Notes

Six isoforms determine the acyl chain length of the ceramide pool.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Sphingolipid homeostasis and dysregulation in liver function and disease.

    Lan J, Pan Z, Dong W, Wang J, Zhang C, Zhang Y, Wu Y, Jin J. · 2026-04-24

    open access unreviewed
  2. 2
    Discovery of a potential CERS2 inhibitor: hit compound identification via structure-based virtual screening and molecular dynamics simulations.

    Yu B, Mo S, Chen Y, Hua Y, Che T, Zhang J, Futerman AH, Duan J. · 2026-01-03

    unreviewed
  3. 3
    GPAM mediates mitochondrial dysfunction and the progression of alcoholic liver disease through lipid remodeling.

    Zhan Z, Liu X, Li Z, Qiao X, Li S, Gong Y, Yang L, Gao Y, Xia X, Bai K, Zeng F, Weng J. · 2026-06-24

    open access unreviewed
  4. 4
    Ceramides in the Heart: Physiological and Pathological Roles and Regulation.

    Chen X, Fonseka O, Han Y, Liu W. · 2026-04-25

    open access unreviewed
  5. 5
    Ceramides as Biomarkers and Pharmacological Targets in Heart Failure Pathophysiology.

    Gaggini M, Vassalle C. · 2026-04-01

    open access unreviewed
  6. 6
    Ceramide in Type 2 Diabetes and Obesity: Modulation by Nutrients and Dietary Patterns and Opportunities to Prevent and/or Manage Metabolic-Related Conditions.

    Gaggini M, Suman AF, Vassalle C. · 2026-04-14

    open access unreviewed
  7. 7
    Listening to Cellular Whispers through Glycosphingolipids: A Comprehensive Review of Recent Advancements in Glycosphingolipid Analysis and Annotation.

    Beirami AD, Rampler E. · 2026-04-17

    open access unreviewed
  8. 8
    The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases.

    Dadzadi M, Ramazi S, Darvazi M, Yoosefi S, Abbasi M, Farsad S. · 2026-03-16

    open access unreviewed
  9. 9
    Targeting Insulin Resistance Through Nutrition: Pathophysiological Insights and Dietary Interventions.

    Caretto A, Zanardini A, Frontino G, Pedone E. · 2026-03-31

    open access unreviewed
  10. 10
    Influenza A Virus Infection Induces Preferential Increases in Long-Chain Ceramides.

    McKenna S, Jung KI, Sumner B, Wolf JJ, Sumner LW, Hahm B. · 2026-03-10

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.