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unreviewed

Ceramide synthase (CerS1-6)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Sphingolipid Synthesis Lipid Metabolism · ER + Golgi

step 3 Irreversible/directional

Sphinganine + fatty acyl-CoA -> dihydroceramide + CoA-SH

Converts Sphinganine Fatty acyl-CoA into Dihydroceramide CoA-SH

› Notes

Six isoforms determine the acyl chain length of the ceramide pool.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Computational evaluation of EPA-PC binding to GCase in neuronopathic Gaucher disease.

    Nagori R, Rai PK, Solanki M, Sabharwal U, Patel P. · 2026-09-08

    open access unreviewed
  2. 2
    Determinants of C<sub>16</sub>-Ceramide Binding to p53.

    Childress MS, Jeffries KA, Krupenko SA, Krupenko NI. · 2026-09-15

    open access unreviewed
  3. 3
    Lipid Metabolic Reprogramming and Bioactive Lipid Signaling in MASLD: Molecular Mechanisms, Pathogenesis and Therapeutic Opportunities.

    Ábel T, Csobod Csajbókné É. · 2026-08-31

    open access unreviewed
  4. 4
    Sphingolipid Metabolism in Oral Diseases: Pathogenic Mechanisms, Biomarkers, and Therapeutic Opportunities.

    Zang S, Huang J, Duan N, Wang W, Wang X, Peng Q, Han W. · 2026-08-12

    open access unreviewed
  5. 5
    The p53-CerS6 interaction on the ER integrates p53 and sphingolipid signaling pathways in metabolic stress response.

    Childress MS, Jeffries KA, Horita DA, Krupenko SA, Krupenko NI. · 2026-07-09

    cited 1× open access unreviewed
  6. 6
    Sphingolipid homeostasis and dysregulation in liver function and disease.

    Lan J, Pan Z, Dong W, Wang J, Zhang C, Zhang Y, Wu Y, Jin J. · 2026-04-24

    open access unreviewed
  7. 7
    Discovery of a potential CERS2 inhibitor: hit compound identification via structure-based virtual screening and molecular dynamics simulations.

    Yu B, Mo S, Chen Y, Hua Y, Che T, Zhang J, Futerman AH, Duan J. · 2026-01-03

    unreviewed
  8. 8
    Posters

    · 2026-07-01

    unreviewed
  9. 9
    Skin Lipid Dysregulation in Atopic Dermatitis and Related Inflammatory Skin Diseases.

    Kim HB, Park J, Lim CS, Um JY, Chung BY, Park CW, Lee DK, Kim HO. · 2026-07-01

    open access unreviewed
  10. 10
    Causal effects of gut microbiota on physical growth and cognitive performance via plasma metabolites: A Mendelian randomization study.

    Yang FF, Luo KP, Liang ZJ, Ou ZX, Li SL, Liang JM, Lin YN. · 2026-07-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.