Carnitine-acylcarnitine translocase (CACT)
Cofactors used
What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
Acylcarnitine (cytosolic side) → acylcarnitine (matrix side)
Converts Acylcarnitine into Acylcarnitine
› Notes
The inner-membrane carnitine–acylcarnitine translocase (CACT) exchanges incoming acylcarnitine for free carnitine moving outward. No ATP is directly consumed.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
The ketogenic diet is not for everyone: contraindications, side effects, and drug interactions.
Dyńka D, Rodzeń Ł, Rodzeń M, Łojko D, Karakuła-Juchnowicz H, Ede G, Grzywacz Ż, Antosik K, Sethi S, Unwin D. · 2026-01-04
cited 4× open access unreviewed -
2
Therapeutic potential of mitochonic acid (MA-5) in modulating mitochondrial function and inflammatory responses: A focus on carnitine/acylcarnitine carrier (SLC25A20) transport activity.
Giangregorio N, Console L, Lentini G, Indiveri C. · 2026-05-30
unreviewed -
3
Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT.
Gao Y, Hao J, Zhang X, Long M, Feng Y, Liu X, Li X, Liu S, Guo X, Lv X. · 2026-07-20
unreviewed -
4
Skeletal muscle carnitine-acylcarnitine translocase deletion reveals vulnerability of oxidative muscle to fatty acid oxidation deficiency.
Jevtovic F, Williamson NC, Pereyra AS, Alexander MK, Spangenburg EE, Ellis JM. · 2026-06-01
unreviewed -
5
KRAS Signaling Inhibition Induces a Targetable Metabolic Dependency on Lipophagy-Dependent Fatty Acid Oxidation in Pancreatic Cancer.
Thakur R, Wang D, Hu T, He C, Zhao J, Suresh V, Rajacharya GH, Pradhan AK, Chumak V, Valenzuela CA, Kushwaha … · 2026-07-01
cited 1× unreviewed -
6
Structure/function relationships of mitochondrial protein carrier (SLC25A20) for carnitine/acylcarnitine: A review.
Giangregorio N, Tonazzi A, Console L, Indiveri C. · 2026-03-22
unreviewed -
7
Mitochondrial Dynamics and SLC25 Transporters in Neurodegeneration: From Mechanisms to Therapeutic Opportunities
Morciano G, Gorgoglione R, Porcelli V, Ahmed A, Scarcia P, Vozza A, Lasorsa F, Fiermonte G, Palmieri L. · 2026-06-01
open access unreviewed -
8
Precision Rehabilitation in Spinal Cord Injury: A Systematic Review of Omics Applications for Intervention Monitoring in Spinal Cord Injury.
Stacul A, Valido E, Nyfeler N, Bertolo A, Zeh RM, Fontana AO, Pannek J, Krebs J, Leichtle A, Glisic M, Stoyan… · 2026-02-16
open access unreviewed -
9
[A case of neonatal fatty acid oxidation disorder].
Deng LL, Zou HM, Cheng TT, Yuan Y, Zhang HY. · 2026-06-01
unreviewed -
10
Peroxisomal Lipid Metabolism as a Therapeutic Target in Leukemia.
Parfenova EN, Spagnuolo PA. · 2026-06-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.