Carnitine palmitoyltransferase II (CPT-2)
Cofactors used
Clinical / pharmacological. CPT-I deficiency: hypoketotic hypoglycaemia, hepatomegaly
What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
Acylcarnitine + CoA-SH → fatty acyl-CoA + carnitine
Converts Acylcarnitine CoA-SH into Fatty acyl-CoA Carnitine
› Notes
Matrix-facing CPT-2 regenerates fatty acyl-CoA and free carnitine. Carnitine returns through CACT; CPT-1, CACT, and CPT-2 together constitute the carnitine shuttle.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Integrated transcriptome and metabolome reveal <i>Mycoplasma hyopneumoniae</i> -induced lipid accumulation, inflammation, oxidative stress, and energy imbalance in the liver of pigs.
Xue X, Bu Y, Yu C, Li J, Yang J, Gao M, Wang P, Gan Y, Zhang W, Fan S, Zhou R, Yin Z, Zheng X. · 2026-06-03
open access unreviewed -
2
mTORC2 regulates lipid metabolism-driven TAMs via the PPAR-γ/CD36 pathway to promote liposarcoma progression.
Xiao W, Sheng J, Liu C, Li J, Shu P, Jiang M, Wang M, He J, Ma H, Ding Y. · 2026-04-29
open access unreviewed -
3
The ketogenic diet is not for everyone: contraindications, side effects, and drug interactions.
Dyńka D, Rodzeń Ł, Rodzeń M, Łojko D, Karakuła-Juchnowicz H, Ede G, Grzywacz Ż, Antosik K, Sethi S, Unwin D. · 2026-01-04
cited 4× open access unreviewed -
4
Fenofibrate attenuates hyperhomocysteinemia-potentiated thrombosis by restoring platelet fatty acid β-oxidation.
Han L, Du X, Yan Y, Zhang L, Feng J, Wang X, Zhang X. · 2026-06-06
open access unreviewed -
5
miR-221-3p-mediated CPT2 suppression links cardiomyocyte metabolic stress to NET-associated inflammation in myocardial ischemia-reperfusion injury: Multi-omics evidence and experimental validation.
Mutailipu M, Aini A, Mutailifu D, Maimaitirexiti S, Maiwulanjiang M, Paerhati D, Maimaitiaili A. · 2026-08-10
unreviewed -
6
A covalent PFKL activator suppresses tumor growth.
Jiang X, Lynch EM, Lyu C, Wilson CN, Salay LE, Hess HT, Lyons SN, Lu MJ, Luo S, Kim G, Chan HR, Wolfe WJ, Zac… · 2026-08-05
unreviewed -
7
Endothelial CPT2 loss impairs fatty acid oxidation and promotes renal fibrosis.
Zhao X, Yu ZX, Browne BM, Li W, Qi YA, Xiong J. · 2026-06-13
unreviewed -
8
High dietary fat causes muscle structural breakdown, mitochondrial dysfunction, and contractile deficits in the absence of carnitine palmitoyltransferase 2.
Pereyra AS, Jevtovic F, Amorese AJ, Lin CT, Neufer PD, Spangenburg EE, Ellis JM. · 2026-06-22
unreviewed -
9
Comprehensive metabolic characterization of pediatric ependymomas.
Li T, Jin Y, Ren S, Liu Y, Cheng D, Bi Z, Li Y, Chen X, Zhu X, Chen Z, He W, Li Y, Liu Y, Luan G, Tian Y, Liu… · 2026-04-20
open access unreviewed -
10
Berberine Regulates Hepatic Fatty Acid Metabolism via AMPK/SIRT1/PGC-1α Pathway.
Guo YJ, Wu F, Gong MM, Wu WB, Lu FE, Wang DK. · 2026-05-13
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.