Carnitine palmitoyltransferase II (CPT-2)
Cofactors used
Clinical / pharmacological. CPT-I deficiency: hypoketotic hypoglycaemia, hepatomegaly
What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
Acylcarnitine + CoA-SH → fatty acyl-CoA + carnitine
Converts Acylcarnitine CoA-SH into Fatty acyl-CoA Carnitine
› Notes
Matrix-facing CPT-2 regenerates fatty acyl-CoA and free carnitine. Carnitine returns through CACT; CPT-1, CACT, and CPT-2 together constitute the carnitine shuttle.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.
Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28
open access unreviewed -
2
Altered Acylcarnitine Metabolism in cardiac diseases: From molecular mechanisms to translational potential.
Wu J, Zhang Y, Liu J, Zhao W, Liu X, Dan J. · 2026-09-25
open access unreviewed -
3
Low-dose l-carnitine supplementation attenuates hepatic lipid accumulation in chow-fed mice: Insights from integrated multi-omics analysis.
Zhang Z, Ding B, Zhang L, Zhang L, Huang Y. · 2026-09-10
open access unreviewed -
4
Distinct functional roles of <i>Lactobacillus</i> strains in modulating lipid metabolism, adipose accumulation, inflammatory responses, and carcass characteristics in heavy finishing pigs.
Wan B, Zeng Q, He L, Qin X, Tan M, Yan E, Liao J, Li Z, Zhang X, Yin J. · 2026-07-31
open access unreviewed -
5
Recent advances in the bioanalysis of acylcarnitines: Methodologies, challenges, and clinical perspectives.
Zheng J, Chen W, Qin F, Zhang P, Xu F. · 2026-06-24
open access unreviewed -
6
<i>Lactobacillus johnsonii</i> mediates the protective effects of pristimerin against ulcerative colitis and concomitant liver injury through remodeling hepatic lipid metabolism via LXRα-SCD1 axis.
Cheng Y, Wu ZE, Huang R, Li Q, Yan D, Chen Y, Zhu W, Li F. · 2026-07-17
open access unreviewed -
7
Integrated transcriptome and metabolome reveal <i>Mycoplasma hyopneumoniae</i> -induced lipid accumulation, inflammation, oxidative stress, and energy imbalance in the liver of pigs.
Xue X, Bu Y, Yu C, Li J, Yang J, Gao M, Wang P, Gan Y, Zhang W, Fan S, Zhou R, Yin Z, Zheng X. · 2026-06-03
cited 1× open access unreviewed -
8
mTORC2 regulates lipid metabolism-driven TAMs via the PPAR-γ/CD36 pathway to promote liposarcoma progression.
Xiao W, Sheng J, Liu C, Li J, Shu P, Jiang M, Wang M, He J, Ma H, Ding Y. · 2026-04-29
open access unreviewed -
9
The ketogenic diet is not for everyone: contraindications, side effects, and drug interactions.
Dyńka D, Rodzeń Ł, Rodzeń M, Łojko D, Karakuła-Juchnowicz H, Ede G, Grzywacz Ż, Antosik K, Sethi S, Unwin D. · 2026-01-04
cited 10× open access unreviewed -
10
Lipid dysregulation in mouse ovarian antral follicles after oral exposure to a human relevant mixture of three phthalates.
Miller KL, Massey T, Metzler V, Adams A, Liu X, Burns K, Porter LR, Snider J, Craig ZR. · 2026-06-06
cited 3× unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.