Carnitine palmitoyltransferase II (CPT-2)
Cofactors used
Clinical / pharmacological. CPT-I deficiency: hypoketotic hypoglycaemia, hepatomegaly
What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
Acylcarnitine + CoA-SH → fatty acyl-CoA + carnitine
Converts Acylcarnitine CoA-SH into Fatty acyl-CoA Carnitine
› Notes
Matrix-facing CPT-2 regenerates fatty acyl-CoA and free carnitine. Carnitine returns through CACT; CPT-1, CACT, and CPT-2 together constitute the carnitine shuttle.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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