Carnitine palmitoyltransferase I (CPT-1)
Cofactors used
Clinical / pharmacological. CPT-I deficiency: hypoketotic hypoglycaemia, hepatomegaly
What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
Fatty acyl-CoA + carnitine → acylcarnitine + CoA-SH
Converts Fatty acyl-CoA Carnitine into Acylcarnitine CoA-SH
› Notes
Carnitine palmitoyltransferase I (CPT-1), located on the outer mitochondrial membrane, transfers the acyl group to carnitine. This is the principal rate-limiting/regulatory step for mitochondrial oxidation of long-chain fatty acids and is inhibited by malonyl-CoA.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Multi-omics characterization of glucose-lipid metabolic remodeling associated with Gymnema sylvestre (Retz.) R.Br. ex Sm. treatment in a type 2 diabetic mouse model.
Zeng Z, Liu Y, Xiao G, Jia C, Wu M, Li Y, Jiang J, Zhang J, Xu A, Bi X. · 2026-06-20
unreviewed -
2
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
3
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
4
FCGR2B drives immunosuppressive M2 polarization of tumor-associated macrophages via metabolic reprogramming of fatty acid oxidation.
Han Z, Rao P, Wang F, Xing Y, Guo X, Du C, Wang Y. · 2026-06-14
unreviewed -
5
Integrated transcriptome and metabolome reveal <i>Mycoplasma hyopneumoniae</i> -induced lipid accumulation, inflammation, oxidative stress, and energy imbalance in the liver of pigs.
Xue X, Bu Y, Yu C, Li J, Yang J, Gao M, Wang P, Gan Y, Zhang W, Fan S, Zhou R, Yin Z, Zheng X. · 2026-06-03
open access unreviewed -
6
Overexpression of SLC44A4 suppresses ferroptosis and reduces lipid peroxidation <i>via</i> noncanonical NF-κB signaling in a NIK-dependent manner.
Li T, Xu Y, Song W, Chang H, He J, Liu S, Liu Z, Xu Y, Yao Q, Song K. · 2026-05-25
open access unreviewed -
7
Soil-derived microbiota induces T regulatory cells and protect against mouse colitis, metabolic disease, and sepsis.
Szurek EA, Ngo VL, Abo H, Cebula A, Chassaing B, Howard RA, Hart M, Hori S, Weaver CT, Gewirtz AT, Ignatowicz… · 2026-05-24
open access unreviewed -
8
A review of the sirtuins family: pivotal regulators and emerging therapeutic targets in renal fibrosis.
Deng Q, Li C, Luo J, Yin M, Qian S, Li L. · 2026-05-14
open access unreviewed -
9
LncRNA H19 as a key regulator in biliary atresia: insights into pathogenesis and potential therapeutic targets.
Zhao Q, He F, Zhang Z, Chen L. · 2026-05-14
open access unreviewed -
10
Microbiota and head and neck cancers: Mechanistic insights and translational potential.
Cui X, Zhang X, Li X, Ma Y, Hu J, Li Z, Yang Y, Ma Z, Liu Y. · 2026-05-11
open access unreviewed
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