CTP:phosphocholine cytidylyltransferase (CCT)
Cofactors used
What it does, reaction by reaction
Phospholipid Synthesis (Kennedy / CDP pathways) Lipid Metabolism · ER / Golgi
Phosphocholine + CTP -> CDP-choline + PPi
Converts Phosphocholine CTP into CDP-choline PPi
› Notes
Rate-limiting step of phosphatidylcholine synthesis; regulated by reversible membrane association of CCT.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
A pcyt-1 allelic series reveals in vivo consequences of reduced phosphatidylcholine synthesis in C. elegans.
Qvist A, Kaper D, Henricsson M, Stjernman A, Borén J, Pilon M. · 2026-08-01
unreviewed -
2
Maternal high-fat high-energy diet impairs surfactant maturation in the non-human primate fetal lung.
Lock MC, Huber HF, Li C, Orgeig S, Nathanielsz PW, Morrison JL. · 2026-04-27
unreviewed - 3
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4
Dose-dependent hormone actions at estrogen receptor enhancers specify distinct molecular and biological outcomes.
Kim HB, Nandu T, Kim YJ, Camacho CV, Kraus WL. · 2026-06-03
open access unreviewed -
5
The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis.
Ariyama H, Tsukamura A, Miyatake S, Okado S, Itabashi I, Ogura A, Suzuki A, Kurakawa H, Sakaguchi Y, Nakatake… · 2026-04-22
open access unreviewed -
6
Nuclear Proteome Map of Mouse Heart Chambers.
Eslami SS, Rai A, Fang H, Thomas A, Cross J, Donner D, Greening DW. · 2026-05-14
open access unreviewed -
7
Clinical and Genetic Insights into Congenital Generalized Lipodystrophy Type 4: A Case Report.
Bilgeç N, Eklioğlu BS, Gün Hİ, Balasar Ö, Atabek ME, Çaksen H. · 2025-09-09
unreviewed -
8
Molecular and Genetic Aspects of Lipid Metabolism Disorders and Potential Targets for Gene Therapy.
Akhmetzyanova ER, Timofeeva AV, Gallyamov DR, Rizvanov AA, Mukhamedshina YO. · 2025-10-30
open access unreviewed -
9
Genotype-first approach reveals monogenic lipodystrophy is underdiagnosed, with health and mortality risks.
Sharp LN, Colclough K, Murray Leech J, Evans AV, Hattersley AT, Weedon MN, Brown RJ, Patel KA. · 2026-04-18
open access unreviewed -
10
Alveolar type 2 cell LRP1 is needed for surfactant phospholipid metabolism and pulmonary function in mice.
Ward R, Krishnan SS, Stavrovskaya I, Sanchez-Gonzalez D, Agudelo CW, Park SS, Mai M, Cai H, Martinez J, Cox K… · 2026-04-16
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.