CTP:phosphocholine cytidylyltransferase (CCT)
Cofactors used
What it does, reaction by reaction
Phospholipid Synthesis (Kennedy / CDP pathways) Lipid Metabolism · ER / Golgi
Phosphocholine + CTP -> CDP-choline + PPi
Converts Phosphocholine CTP into CDP-choline PPi
› Notes
Rate-limiting step of phosphatidylcholine synthesis; regulated by reversible membrane association of CCT.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Tumor‑immune spatiotemporal co‑evolution: A new paradigm for understanding and overcoming therapy resistance in metastatic castration‑resistant prostate cancer (Review).
Yan L, Sun X, Su P. · 2026-09-25
open access unreviewed -
2
Diet-Induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas.
Ruiz CF, Ge X, McDonnell R, Agabiti SS, McQuaid DC, Tang A, Kharwa M, Goodell J, Saavedra-Peña RDM, Wing A, L… · 2026-10-01
cited 5× unreviewed -
3
Lipodystrophy in Central Asia: A Regional Literature Review with a Case Series of Congenital and Acquired Generalized Lipodystrophy.
Rakhimzhanova M, Bimurat B, Jangashkarova A, Issabayeva A, Durmanova A, Alzhaxina A, Ivanova-Razumova T, Rapi… · 2026-09-14
open access unreviewed -
4
Advances in RNA m6A modification research and its role in poultry economic traits.
Liu J, Liu H, Huang X, Xiao Z, Li S, Hu X, Liu S, Mao H, Chen B. · 2026-09-14
open access unreviewed -
5
Time-Dependent Phospholipid Remodeling in Cultured Primary Mouse Hepatocytes: Associations with PEMT Status and Methionine Availability.
Ma T, Zhou K, Zhu Y, Zhang J, Xie X, Zhang L, Ye C, Tu ZC. · 2026-09-03
open access unreviewed -
6
Targeting 3-mercaptopyruvate sulfurtransferase selectively eliminates colorectal cancer stem cells.
Ascenção K, Oravecz O, Szabo C. · 2026-09-02
open access unreviewed -
7
Biosynthesis of Phosphatidylethanolamine and Phosphatidylcholine via the Kennedy Pathway in Cancer and Other Pathological Conditions.
Korbecki J, Bosiacki M, Chlubek M, Dzięciołowska-Baran E, Lubkowski M, Kabacińska K, Barczak K. · 2026-08-22
open access unreviewed -
8
Regulatory T Cell (Treg): Central Orchestrator of Immune Homeostasis.
Salam MA, Al-Amin MY, Sudarshan K, Whalen N, Chapman F, Gideon C, Cordovez A. · 2026-08-15
open access unreviewed -
9
MetaboGraph: A Framework for Metabolomics and Lipidomics Annotation and Pathway Network Analysis.
Daramola O, Nwaiwu J, Oluokun O, Fowowe M, Mechref Y. · 2026-08-01
cited 2× open access unreviewed -
10
Endogenous phosphatidylcholine 16:0/20:4 increases to promote liver regeneration in hepatectomy.
Cen L, Wang Y, Yang J, Shi W, Lin P, Zhang W, Xiang X, Gao X, Huang J, Fang J, Yu X, Dai M, Liu A, Lu C. · 2026-07-31
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.