1-Acylglycerol-3-phosphate acyltransferase (AGPAT)
Cofactors used
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
Lysophosphatidic acid + fatty acyl-CoA → phosphatidic acid (1,2-diacyl-glycerol-3-phosphate) + CoA-SH
Converts Lysophosphatidic acid Fatty acyl-CoA into Phosphatidic acid CoA-SH
› Notes
1-Acylglycerol-3-phosphate acyltransferase (AGPAT) adds the second acyl chain at sn-2.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Role of mitochondria-associated ER membranes in lipid metabolism: implications for renal lipotoxicity.
Gao Y, Shao M, Fang Y, Zeng J, Sun H. · 2026-09-01
open access unreviewed -
2
Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging.
Zhao X, Feitzinger RM, Na J, Yan X, Erickson A, Contrepois K, Zhou OY, Vallania F, Ellenberger M, Kashiwagi C… · 2026-07-29
cited 2× open access unreviewed -
3
AGPAT family members act as potential predictive biomarkers and therapeutic targets in cervical cancer.
Gui N, Pan H, Lu W, Pan G, Zhou X, Chen Y, Jin M, Yang C, Dong M, Liang Y. · 2026-06-09
open access unreviewed -
4
ATF3 Modulates the Endoplasmic Reticulum Stress-Induced Impairment of Milk Synthesis in Bovine Mammary Epithelial Cells.
Zhang C, Dai W, Liu Y, Xu H, Liu H. · 2026-05-10
open access unreviewed -
5
Curcumin ameliorates metabolic dysfunction-associated steatotic liver disease <i>via</i> targeting triokinase/FMN cyclase to regulate the expression of glycerol-3-phosphate acyltransferase 3: Integration of chemical proteomics and transcriptomics.
Zhao C, Li P, Shi J, Cao S, Guo Y, Li G, Kang N, Qiu F. · 2026-02-02
cited 1× open access unreviewed -
6
Lipid droplet dynamics in metabolic regulation.
Weiskirchen R, Weiskirchen S, Lonardo A. · 2026-03-25
cited 4× open access unreviewed -
7
Lipid metabolism in homeostasis and disease.
Li Z, Deng W, Yang L, Tang C, Yue JM, Monteiro O, Baptista-Hon DT, Li T. · 2026-02-16
cited 23× open access unreviewed -
8
An evolutionary analysis of lysophospholipid acyltransferases generating membrane phospholipid diversity.
Shindou H, Kawai Y. · 2026-08-10
open access unreviewed -
9
Prognostic impact of the lipid metabolism gene AGPAT4 in the tumor immune microenvironment of thyroid cancer.
Zhu Y, Xu W, Bai X, Qiao Y, Ye D. · 2026-01-10
open access unreviewed -
10
Gut microbiota regulates hepatic ketogenesis and lipid accumulation in ketogenic diet-induced hyperketonemia by disrupting bile acid metabolism.
Luo Z, Huang Y, Yong K, Wu D, Zheng L, Yao X, Shen L, Yu S, Wang B, Cao S. · 2025-04-23
cited 15× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.