1-Acylglycerol-3-phosphate acyltransferase (AGPAT)
Cofactors used
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
Lysophosphatidic acid + fatty acyl-CoA → phosphatidic acid (1,2-diacyl-glycerol-3-phosphate) + CoA-SH
Converts Lysophosphatidic acid Fatty acyl-CoA into Phosphatidic acid CoA-SH
› Notes
1-Acylglycerol-3-phosphate acyltransferase (AGPAT) adds the second acyl chain at sn-2.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
AGPAT family members act as potential predictive biomarkers and therapeutic targets in cervical cancer.
Gui N, Pan H, Lu W, Pan G, Zhou X, Chen Y, Jin M, Yang C, Dong M, Liang Y. · 2026-06-09
unreviewed -
2
ATF3 Modulates the Endoplasmic Reticulum Stress-Induced Impairment of Milk Synthesis in Bovine Mammary Epithelial Cells.
Zhang C, Dai W, Liu Y, Xu H, Liu H. · 2026-05-10
open access unreviewed -
3
Curcumin ameliorates metabolic dysfunction-associated steatotic liver disease <i>via</i> targeting triokinase/FMN cyclase to regulate the expression of glycerol-3-phosphate acyltransferase 3: Integration of chemical proteomics and transcriptomics.
Zhao C, Li P, Shi J, Cao S, Guo Y, Li G, Kang N, Qiu F. · 2026-02-02
open access unreviewed -
4
Lipid droplet dynamics in metabolic regulation.
Weiskirchen R, Weiskirchen S, Lonardo A. · 2026-03-25
cited 1× open access unreviewed -
5
Lipid metabolism in homeostasis and disease.
Li Z, Deng W, Yang L, Tang C, Yue JM, Monteiro O, Baptista-Hon DT, Li T. · 2026-02-16
cited 15× open access unreviewed -
6
Prognostic impact of the lipid metabolism gene AGPAT4 in the tumor immune microenvironment of thyroid cancer.
Zhu Y, Xu W, Bai X, Qiao Y, Ye D. · 2026-01-10
open access unreviewed -
7
Gut microbiota regulates hepatic ketogenesis and lipid accumulation in ketogenic diet-induced hyperketonemia by disrupting bile acid metabolism.
Luo Z, Huang Y, Yong K, Wu D, Zheng L, Yao X, Shen L, Yu S, Wang B, Cao S. · 2025-04-23
cited 4× open access unreviewed -
8
Integrative Analysis of Differentially Expressed miRNAs and Noncoding RNA Networks Reveals Molecular Mechanisms Underlying Metritis in Postpartum Dairy Cows.
Kasimanickam R, Ferreira J, Kasimanickam V. · 2025-08-11
open access unreviewed -
9
Lipid droplet accumulation in microglia and their potential roles.
Li Y, Zhao Q, Wang Y, Du W, Yang R, Wu J, Li Y. · 2025-06-14
cited 9× open access unreviewed -
10
Genomic regions associated with bovine respiratory disease in pacific northwest Holstein cattle.
Herrick AL, Kiser JN, White SN, Neibergs HL. · 2025-07-31
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.