unreviewed

Betaine–homocysteine methyltransferase (BHMT)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol

step 5 Irreversible/directional

Homocysteine + betaine → methionine + dimethylglycine

Converts Homocysteine Betaine into Methionine Dimethylglycine

› Notes

Betaine–homocysteine methyltransferase (BHMT) uses betaine (trimethylglycine) as methyl donor in liver and kidney. This folate- and B12-independent alternative remethylation pathway is especially important when choline/betaine supply is adequate.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine)

Listed there as: Betaine–homocysteine methyltransferase

Accelerated by

Betaine/choline availability; homocysteine

Inhibited by

Low betaine availability

Hormonal control

Dietary choline and hepatic nutritional state dominate regulation

Recent literature

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Europe PMC · fetched just now · sorted by publication date

1
Hypochlorite detection via the irreversible imine-bond cleavage by a practical fluorescent sensor: applications to smartphone-assisted environmental water and food bioimaging.
Lee A, Batsaikhan O, Lee HS, Kim KT, Kim C. · 2026-08-03

unreviewed
2
Dietary Dihydromyricetin Supplementation Enhances Antioxidant Capacity and Modulates Jejunal Barrier Function, Cecal Microbiota, and Hepatic Metabolism in Mice.
Liang W, Tang L, Fan J, Huang R, Chen J, Qian L. · 2026-07-22

unreviewed
3
Excessive maternal methionine intake increases the incidence of congenital anomalies of the kidney and urinary tract in offspring mice.
Ye N, Yu M, Ju H, Jiang Y, Zhang Y, Sun L, Wu X, Chen J, Xu H, Shen Q. · 2026-07-06

unreviewed
4
Plasma Exosomes Associated with Growth Divergence in High-Density Cultured Grass Carp (Ctenopharyngodon idella): miRNA-Protein Profiling Reveals Cross-Tissue Communication Networks.
Zhu T, Zheng Z, Chen H, Yu Y, Guo H, Liu B, Zhu K, Zhang N, Xian L, Zheng S, Liu Y, Chen S, Zhang D. · 2026-07-06

unreviewed
5
Choline-dependent methionine metabolism supports leukemia progression.
Saha N, Lachowski L, Franzen F, Alibeckoff S, Vitvitsky V, Kumar R, Hutchings M, Kandarpa M, Hu H, Ropa J, Ai… · 2026-07-02

unreviewed
6
Methionine Synthase Interacts With the Methionine Adenosyl-Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus.
Jeandel M, Alberto JM, Baspinar O, Robert A, Dreumont N, Alsahly Z, Meyre D, Guéant JL, Coelho D. · 2026-07-01

open access unreviewed
7
NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine.
Nakajima W, Arisawa T, Jitsuki S, Yamanoue T, Fujikawa K, Hara M, Sano A, Takada Y, Iai R, Kimura K, Suzuki M… · 2026-03-23

open access unreviewed
8
Effects of Dietary Betaine on Growth Performance, Serum Metabolites, and Meat Quality of Pigs: A Meta-Analysis
Liu G, Wang Y, Dong X, Wang H. · 2026-06-01

open access unreviewed
9
Untargeted metabolomics and proteomics reveals cocoa-mediated mitigation of valproic acid-induced dysregulation in a zebrafish model of autism: pilot study.
Li J, Haj-Husein I, Ghafari N, Khorraminezhad L, Iskandar M, Zaouter C, Klein M, Sleno L, Patten SA, Kubow S. · 2026-06-18

open access unreviewed
10
Complementary hyperpolarized 13C and 15N MRI reveal divergent signatures of hepatic injury and methyl-donor metabolism.
Skre IS, Karlsson M, Sánchez-Heredia JD, Skre VS, Rasmussen PA, Lerche MH. · 2026-06-17

open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.