Betaine–homocysteine methyltransferase (BHMT)
What it does, reaction by reaction
Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol
Homocysteine + betaine → methionine + dimethylglycine
Converts Homocysteine Betaine into Methionine Dimethylglycine
› Notes
Betaine–homocysteine methyltransferase (BHMT) uses betaine (trimethylglycine) as methyl donor in liver and kidney. This folate- and B12-independent alternative remethylation pathway is especially important when choline/betaine supply is adequate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Methionine Cycle / Transmethylation (SAM Cycle, homocysteine)
Listed there as: Betaine–homocysteine methyltransferase
Betaine/choline availability; homocysteine
Low betaine availability
Dietary choline and hepatic nutritional state dominate regulation
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Genomic characterization of a MAGIC population containing introgressions from four tetraploid Gossypium species.
Pinnika G, Li P, McCarty JC, Jenkins JN, Fang DD. · 2026-12-01
open access unreviewed -
2
Homocysteine, cysteine and methionine are associated with 90-day prognosis in intracerebral hemorrhage patients.
Fang M, Xia T, Yin Y. · 2026-08-21
open access unreviewed -
3
Standardizing Cell Ontology terms for cross-study integration in the female reproductive tract
Ong H, Saunders D, Eastwood C, Puig-Barbe A, Kochersberger A, Galligos A, Marshall B, Johnson B, Kratka C, Ji… · 2026-10-09
open access unreviewed -
4
<sup>1</sup>H HR-MAS NMR Metabolomics in Combination With Transcriptomic Correlation Provides New Insights Into Metabolic Heterogeneity Across Breast Cancer Immunohistochemical Subtypes.
Garcia-Bocanegra I, Urbano-Gamez JD, Perez-Cardona A, Barrios L, Somoza-Ramírez MI, Vicioso L, Pardo-Susacasa… · 2026-10-01
open access unreviewed -
5
Hypochlorite detection via the irreversible imine-bond cleavage by a practical fluorescent sensor: applications to smartphone-assisted environmental water and food bioimaging.
Lee A, Batsaikhan O, Lee HS, Kim KT, Kim C. · 2026-08-03
unreviewed -
6
Nutrigenomic regulation of one-carbon metabolism and the circadian clock in health and disease.
Fustin JM. · 2026-10-01
open access unreviewed -
7
Global and mitochondrial choline dehydrogenase contribute to goose fatty liver formation by differentially regulating energy metabolism, autophagy and oxidative stress related pathways.
Zhou X, Lv M, Xing Y, Zhao X, Mao M, Zhao M, Gong D, Liu C, Geng T, Ge J. · 2026-06-14
open access unreviewed -
8
Advanced Ophthalmic Drug Delivery in Homocystinuria Type CblC: A Translational Review of Ophthalmic Pathologies and Therapeutic Opportunities.
Cuello-Rodríguez S, Sanna M, Lecoeuche I, Sarmento B, Otero-Espinar FJ, Díaz-Tomé V. · 2026-09-19
open access unreviewed -
9
REV-ERB-Mediated Regulation of Neural Functional Mechanisms by Phytochemicals in the Circadian System.
Pan MY, Wang JB, Li R, Wang ZY, Lu MW, Huang JQ. · 2026-09-20
open access unreviewed -
10
S-Adenosylmethionine-Dependent Methylation, Protein Arginine Methyltransferases and Cardiovascular Diseases.
Yan Z, Zhao W, Zhao N, Li J. · 2026-09-19
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.