unreviewed

Betaine–homocysteine methyltransferase (BHMT)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol

step 5 Irreversible/directional

Homocysteine + betaine → methionine + dimethylglycine

Converts Homocysteine Betaine into Methionine Dimethylglycine

› Notes

Betaine–homocysteine methyltransferase (BHMT) uses betaine (trimethylglycine) as methyl donor in liver and kidney. This folate- and B12-independent alternative remethylation pathway is especially important when choline/betaine supply is adequate.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine)

Listed there as: Betaine–homocysteine methyltransferase

Accelerated by

Betaine/choline availability; homocysteine

Inhibited by

Low betaine availability

Hormonal control

Dietary choline and hepatic nutritional state dominate regulation

Recent literature

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