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unreviewed

Beta-alanine transaminase (AGXT2)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Pyrimidine Degradation Nucleotide Metabolism · Cytosol

step 12 Irreversible/directional

Beta-alanine → malonate semialdehyde → acetyl-CoA

Converts beta-Alanine into Malonate semialdehyde

› Notes

Beta-alanine transaminase (largely AGXT2-associated activity) transfers the amino group of beta-alanine to an alpha-ketoacid acceptor, producing malonate semialdehyde. Malonate-semialdehyde dehydrogenase (ALDH6A1) then catalyzes oxidative decarboxylation of malonate semialdehyde with CoA and NAD+ to form acetyl-CoA, CO2, and NADH; exact transaminase partners vary by tissue.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Proteomic mapping of Rosa damascena nanovesicles reveals plastid mitochondrial metabolic convergence and antimicrobial peptides.

    Brahadeeswaran S, Tamizhselvi R. · 2026-03-09

    open access unreviewed
  2. 2
    Carnosine-Related Metabolism in Rat Cardiomyocytes and Human Heart Tissue.

    Creighton JV, de Souza Gonçalves L, Gil S, Vargas BS, Jensen L, de Medeiros MHG, Roschel H, Turner MD, Doig C… · 2026-07-01

    unreviewed
  3. 3
    Multi-omics and spatial proteomic profiling reveal novel AGXT2<sup>-</sup> PYCR3<sup>-</sup> macrophages and their phenotypes in metabolic dysfunction-associated steatotic liver disease.

    Lv T, Dai H, Zhang S, Chang E, Ni M, Ge J, Cao Y, Cheng Z, He Y, Huai J, Ma W, Zhu Y, Xu X, Yan Q, Fang Z, Yu… · 2026-07-13

    unreviewed
  4. 4
    Transcriptome and co-expression network analysis identified candidate genes for intramuscular fat deposition in chickens.

    Wang H, Wang C, Zhao W, Yu B, Hu J, Zhang J, Gu Y. · 2026-07-03

    unreviewed
  5. 5
    Circulating nitric oxide pathway metabolites in heart failure with preserved ejection fraction: a sex-stratified cross-sectional analysis.

    Dinges SM, Schwedhelm E, Baldassarri F, Haller B, Gevaert AB, Böger R, Winzer EB, Edelmann F, Wisløff U, Adam… · 2026-06-15

    cited 1× open access unreviewed
  6. 6
    ADAMTS4 elicits myeloid-derived immune cell recruitment and liver fibrogenesis in metabolic dysfunction-associated steatotic liver disease.

    Park J, Kim T, Shim WS, Hong SE, Park M, Oh S, Koo BK, Lee DH, Joo SK, Yoo T, Lee YJ, Lim SC, Seo SY, Kim KM,… · 2026-05-06

    open access unreviewed
  7. 7
    Moyamoya syndrome in a patient with pathogenic heterozygous variant in the <i>SETD5</i> gene: A case report.

    Dams L, Milewicz DM, Bauer P, Kraemer M. · 2025-04-03

    open access unreviewed
  8. 8
    Hepatic-Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi-Omics Analysis of Tumors With Lymphovascular Invasion.

    Yajima S, Tsukada Y, Yamashita R, Fujisawa T, Kuwata T, Watanabe R, Ishii G, Gabelia N, Juhl H, Koga Y, Yoshi… · 2026-04-01

    open access unreviewed
  9. 9
    Functional CRISPR Screens Define Genetic Drivers for Cancer Transformation and Progression from Non-Cancerous Cells.

    Ma S, Li Y, Fei T. · 2026-04-02

    open access unreviewed
  10. 10
    Unbiased Discovery of Genetic Determinants of Resilience to CAD: Insights From PROMISE and CATHGEN.

    Zhbannikov I, Ginsburg GS, Ferencik M, Foldyna B, Ruggles KV, Kraus WE, Pagidipati N, Lu MT, Shah S, Douglas … · 2026-03-18

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.