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unreviewed

Aspartate aminotransferase (AST / GOT)

1 reactions · 1 pathways

Cofactors used

PLP (B6) · B6 (Pyridoxine)

What it does, reaction by reaction

1 reactions

Transamination Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion

step 4 Reversible

L-aspartate + α-ketoglutarate ⇌ oxaloacetate + L-glutamate

Converts Aspartate Alpha-ketoglutarate into Oxaloacetate Glutamate

› Notes

Aspartate aminotransferase (AST/GOT) catalyzes this PLP-dependent, reversible reaction. In liver, aspartate supplies one of the two nitrogens of urea; mitochondrial AST also participates in the malate–aspartate shuttle.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Evaluation of subacute toxicity of highly bioavailable curcuRouge® formulation by a repeated dose 28-day oral exposure toxicology study in sprague dawley rats with safety assessment.

    Kapoor MP, Musumi K, Katsuura Y, Aoyama H, Kochizawa M, Tanigaki K, Kishimoto A, Hashimoto T. · 2026-08-27

    open access unreviewed
  2. 2
    Carryover effects of dietary arginine on productive performance and blood biochemistry in Japanese quail (<i>Coturnix japonica</i>).

    Gashew M, Reda GK, Knop R, Szabó C, Lendvai ÁZ, Czeglédi L. · 2026-07-19

    open access unreviewed
  3. 3
    A dual-gene-deleted ASFV Lv17/WB/Rie1-ΔCD candidate administered orally to wild boar confers DIVA-compatible protection against virulent challenge.

    Barasona JA, Kosowska A, González-García G, Díaz-Frutos M, Franzoni G, Nicolussi P, Porras N, Sánchez-Segovia… · 2026-03-26

    open access unreviewed
  4. 4
    Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth in <i>GNAS</i> (Gα<sub>s</sub>) mutant pancreas cancer.

    Hagedorn GA, Spieser JC, Hirai N, Sato Y, Valentine J, Jiang H, Wang W, Czyzyk-Krzeska MF, Patra KC. · 2026-09-30

    open access unreviewed
  5. 5
    Disease-specific tau polymorphs are associated with unique protein networks across proteinopathies.

    Puangmalai N, Bhatt N, Suthprasertporn N, Miranda-Morales EG, Shchankin N, Samples M, Balci AE, Liew JY, Mont… · 2026-08-18

    open access unreviewed
  6. 6
    Comparative Evaluation of the Functional and Immunomodulatory Properties of Raw and Spray-Dried Donkey Milk.

    Plotuna AM, Hotea I, Imre K, Herman V, Nichita I, Popa I, Pop M, Tîrziu E. · 2026-09-15

    open access unreviewed
  7. 7
    Malate-aspartate shuttle inactivation drives pulmonary hypertension through glucose carbon flux rewiring and α-ketoglutarate-dependent epigenetic remodeling.

    Wang Y, Liang Q, Gao Y, Geng J, Cheng X, Xin M, Guo D, Sun D, Hu L, Li Y, Jin F. · 2026-09-15

    open access unreviewed
  8. 8
    Japanese encephalitis virus reprograms host pyrimidine metabolism to facilitate viral replication.

    Gu J, Fan C, Xiang S, Si Y, Zhu B, Cao S, Ye J. · 2026-07-31

    open access unreviewed
  9. 9
    Differential metabolic and cellular brain regional susceptibility in adult rats with chronic liver disease.

    Simicic D, Pierzchala K, Braissant O, Sessa D, McLin V, Cudalbu C. · 2026-09-11

    open access unreviewed
  10. 10
    Processing enhances the anti-hepatocellular carcinoma effect of Momordicae Semen via remodeling chemical composition and regulating the Akt/mTOR/STAT3 pathway.

    Fang L, Liu M, Han R, Hong Y, Han Y. · 2026-08-05

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.