Aspartate aminotransferase (AST / GOT)
Cofactors used
What it does, reaction by reaction
Transamination Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
L-aspartate + α-ketoglutarate ⇌ oxaloacetate + L-glutamate
Converts Aspartate Alpha-ketoglutarate into Oxaloacetate Glutamate
› Notes
Aspartate aminotransferase (AST/GOT) catalyzes this PLP-dependent, reversible reaction. In liver, aspartate supplies one of the two nitrogens of urea; mitochondrial AST also participates in the malate–aspartate shuttle.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Carryover effects of dietary arginine on productive performance and blood biochemistry in Japanese quail (<i>Coturnix japonica</i>).
Gashew M, Reda GK, Knop R, Szabó C, Lendvai ÁZ, Czeglédi L. · 2026-07-19
unreviewed -
2
A dual-gene-deleted ASFV Lv17/WB/Rie1-ΔCD candidate administered orally to wild boar confers DIVA-compatible protection against virulent challenge.
Barasona JA, Kosowska A, González-García G, Díaz-Frutos M, Franzoni G, Nicolussi P, Porras N, Sánchez-Segovia… · 2026-03-26
open access unreviewed -
3
Physiological Responses and Safety Evaluation of Combined Fremont™ Snare and Medetomidine-Ketamine-Acepromazine Immobilization in Free-Ranging Apennine Wolves (<i>Canis lupus italicus</i>).
Angelucci S, Tana FD, Oliveira C, Almeida JM, Carafa M, Gandolfi M, Petrizzelli L, Domenico GD, Di Francesco … · 2026-06-04
open access unreviewed -
4
Integrated metabolomics and transcriptomics reveal metabolite differences between wild and cultivated Angelica sinensis.
Zeng Q, Gong M, Jiang R, Lei J, Chen Z, Wu H, Sun L, Xu X, Chen W. · 2026-06-06
unreviewed -
5
Identification of Foxm1 as a critical regulator for metabolic dysfunction-associated steatotic liver disease by epigenomic and transcriptional profiling.
Zeng C, Wei M, Li H, Niu F, Guo Z, Li LY, Wu M, Chen MK. · 2026-04-14
open access unreviewed -
6
Introducing the J-CONNECT database: a real-world oncology resource for Japan.
Okada M, Matsumoto S, Maehara Y, Kanayama T, Lambrelli D, Koga T, Muto M. · 2026-04-24
open access unreviewed -
7
The plant hormone, 6-benzylaminopurine, ameliorates obesity in male and female mice while on a high-fat diet.
Lieu CV, Zhang CX, Loganathan N, French L, Krunic A, Cash SB, Shi J, Lee J, Prentice KJ, Cummins CL, Gillis J… · 2026-04-11
open access unreviewed -
8
Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells.
Tang N, Gong Y, Zhao C, Niu Y, Tan L, Song C, Qiu X, Liao Y, Yu S, Ding C, Lin S, Sun Y. · 2026-04-09
open access unreviewed -
9
Ameliorative potential of pomegranate juice against synthetic colorant (E124)-induced biochemical and histopathological changes in the rat brain and testes.
Alqahtani NS, Hassan HM, Rashied RM, Tony SK, Megahed EM. · 2026-03-24
open access unreviewed -
10
Tracking of [<sup>14</sup>C]Polystyrene Nanoplastics in Pregnant Mice.
Khaybullina O, Sarkhel P, Keinänen OM. · 2026-03-24
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.