Aromatic L-amino acid decarboxylase (DDC)
Cofactors used
Clinical / pharmacological. Peripheral inhibition by carbidopa allows levodopa CNS delivery
What it does, reaction by reaction
Catecholamine Synthesis Amino Acid & Nitrogen Metabolism · Cytosol + secretory vesicle
L-DOPA -> dopamine + CO2
Converts L-DOPA into Dopamine CO2
› Notes
Peripheral inhibition of DDC by carbidopa is what allows levodopa to reach the brain.
Serotonin & Melatonin Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
5-Hydroxytryptophan -> serotonin (5-HT) + CO2
Converts 5-Hydroxytryptophan into Serotonin (5-HT) CO2
› Notes
Serotonin is degraded by MAO to 5-HIAA, the urinary marker of carcinoid syndrome.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Engineering short-sequence elements for condensate-like assemblies by de novo design.
Zhang D, Zhang B, Zheng C, Sun W, Niu H, Zhu C, Chen Y, Liu D, Ying H. · 2026-07-18
cited 1× open access unreviewed -
2
A selective inhibitor reveals roles for LONP1 in mitochondrial proteostasis and OXPHOS dependencies.
Szilagyi Z, Michon P, Pardo-Hernández C, Sãcultanu M, Miralles Fusté J, Griffin AM, Charifson PS, Phan C, Shi… · 2026-10-01
open access unreviewed -
3
DNA-PKcs and PARP1 at the interface between DNA damage responses and cGAS-STING signaling: context-dependent roles and therapeutic implications.
Miao T, Zhao J, Wu J, Hou J, Ma T, Wang G. · 2026-09-08
open access unreviewed -
4
<i>Phocaeicola coprocola</i> attenuates liver fibrosis by modulating extracellular matrix remodeling.
Lee KJ, Park JH, Park H, Kim MJ, Yoon H, Kim JM, Han SH, Suk KT. · 2026-08-17
open access unreviewed -
5
HSV-1 metabolic hijacking: Mechanisms to precision therapeutics.
Kuang S, Zhang J, Chen J, He Z, Yang J, Li S, Ding J, Ma Z, Zhang B. · 2026-08-11
open access unreviewed -
6
Mechanistic pathways linking gut microbial metabolites, microbial structural products, and host-microbe co-metabolites to mitochondrial function.
Frye RE, Rossignol DA. · 2026-08-06
open access unreviewed -
7
Context matters in PROTAC design: navigating the trade-off between degradation and developability.
Zhang B, Zhang Y, Zhang B, Hu J, Ke C, Wu T, Wei M, Xia J, Wang M, Zhao Q, Tian L, Liang C. · 2026-08-04
open access unreviewed -
8
Biomimetic membrane-coated metal nanoplatforms for enhanced BBB penetration and targeted glioblastoma therapy.
Yun D, Mu L, Liu J, Li C, Zhao S, Zhai Q, Sun H, Wu X, Shi K, Fan W. · 2026-07-13
open access unreviewed -
9
'Finding Solid Ground' in inpatient treatment for dissociative disorder patients followed by transition to outpatient treatment settings: a one-year follow-up pilot study.
Jepsen EKK, Langeland W, Frost K, Sele P. · 2026-07-24
open access unreviewed -
10
Vitamin B6 produced by gut microbiome regulates host behavioral phenotypes through dopaminergic metabolism.
Kim D, Li M, Nguyen TH, Choi YJ, Jang S, Kim M, Kim YK, Shin MK, de Guzman ACV, Park S. · 2026-07-03
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.