Aromatic L-amino acid decarboxylase (DDC)
Cofactors used
Clinical / pharmacological. Peripheral inhibition by carbidopa allows levodopa CNS delivery
What it does, reaction by reaction
Catecholamine Synthesis Amino Acid & Nitrogen Metabolism · Cytosol + secretory vesicle
L-DOPA -> dopamine + CO2
Converts L-DOPA into Dopamine CO2
› Notes
Peripheral inhibition of DDC by carbidopa is what allows levodopa to reach the brain.
Serotonin & Melatonin Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
5-Hydroxytryptophan -> serotonin (5-HT) + CO2
Converts 5-Hydroxytryptophan into Serotonin (5-HT) CO2
› Notes
Serotonin is degraded by MAO to 5-HIAA, the urinary marker of carcinoid syndrome.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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