Argininosuccinate lyase (ASL)
Clinical / pharmacological. Argininosuccinic aciduria
What it does, reaction by reaction
Urea Cycle Amino Acid & Nitrogen Metabolism · Mitochondrial matrix + cytosol
Argininosuccinate → L-arginine + fumarate
Converts Argininosuccinate into Arginine Fumarate
› Notes
Cytosolic argininosuccinate lyase (ASL) cleaves argininosuccinate without a required redox cofactor. Fumarate enters the aspartate–argininosuccinate shunt, where it can be converted through malate and oxaloacetate to aspartate, linking the cycle to the tricarboxylic acid cycle.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects.
Zhang L, Fan Y, Shi W, Zhou X. · 2026-07-16
open access unreviewed -
2
A Computational Framework for Myelin as a Regulator of Temporal Integration, Neuronal Excitability, and Synaptic Plasticity.
O'Sullivan D, Pariz A, Trotter D, Al Dahhan NZ, Knowles JK, Frankland PW, Mabbott D, Lefebvre J. · 2026-12-01
open access unreviewed -
3
Proteomics of heterogeneous megakaryocytes identifies JI051 as an enhancer of platelet biogenesis.
Taga R, Kuwano N, Harada Y, Hayashi T, Sakamoto Y, Fujio K, Kakumoto Y, Nakamura E, Eto K, Hayashi H. · 2026-09-23
open access unreviewed -
4
Effects of MC-100093, GLT-1 enhancer, in mesolimbic brain regions of C57BL/6 mouse exposed to hydrocodone high-dose challenge using comprehensive laboratory monitoring system.
Wong W, Bhowmik KK, Childers WE, Abou-Gharbia M, Sari Y. · 2026-09-10
open access unreviewed -
5
Impact of MRI modality selection on glioma sub-region segmentation using 3D U-Net and Attention U-Net: A comparative evaluation across ten MRI sequences.
Khorasani A. · 2026-09-14
open access unreviewed -
6
Analytical description of adverse events with long-acting injectable cabotegravir and rilpivirine in people living with HIV: a large multicentre prospective observational cohort study (SCOLTA).
Cologgi G, Ricci E, Di Biagio A, Ferrara S, Orofino G, Squillace N, Pontali E, Menzaghi B, Sarchi E, Cenderel… · 2026-09-21
unreviewed -
7
Cognitive fatigue is related to reduced cerebral perfusion and sustained attention in patients with post COVID-19 condition: An fMRI study.
Hedberg SM, Borg K, Stenberg J, Hedström S, Granberg T, Gyllenberg A, Petersson S, Van Loo H, Nordin LE, Möll… · 2026-09-12
unreviewed -
8
Eye-tracking and cognitive patterns in post-traumatic stress disorder: a scoping review.
Diotaiuti P, Spica G, Di Siena F, Cavicchiolo E, De Souza LC, Andrade A, Mancone S. · 2026-09-14
open access unreviewed -
9
Predicting early psychiatric readmission among people with major depressive disorder: A machine learning analysis from the prospective multicentre DEEP READ study.
Bartoli F, Luciano M, Crocamo C, Bassetti C, Cavaleri D, Aguglia A, Atti AR, Berardelli I, Cecere AC, Cipolla… · 2026-09-13
unreviewed -
10
Dose-response meta-analysis of dual orexin receptor antagonists on sleep parameters and implications for orexin-mediated arousal.
Caiazza C, Palagini L, Toni C, Maffucci A, Sampogna G, Riemann D, Fiorillo A. · 2026-09-07
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.