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unreviewed

Argininosuccinate lyase (ASL)

1 reactions · 1 pathways

Clinical / pharmacological. Argininosuccinic aciduria

What it does, reaction by reaction

1 reactions

Urea Cycle Amino Acid & Nitrogen Metabolism · Mitochondrial matrix + cytosol

step 4 Irreversible/directional

Argininosuccinate → L-arginine + fumarate

Converts Argininosuccinate into Arginine Fumarate

› Notes

Cytosolic argininosuccinate lyase (ASL) cleaves argininosuccinate without a required redox cofactor. Fumarate enters the aspartate–argininosuccinate shunt, where it can be converted through malate and oxaloacetate to aspartate, linking the cycle to the tricarboxylic acid cycle.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    The relative immunogenicity of 20-valent and 15-valent pneumococcal conjugate vaccines: A systematic review and network meta-analysis.

    Valentini I, Strangi EA, Baccarini G, Martini C, Paoloni M, Mannocci A, de Waure C. · 2026-07-20

    unreviewed
  2. 2
    The effects of <i>Saccharomyces boulardii</i> on TLR4/NF-κB neuroinflammatory pathway in the hippocampus of LPS-induced rats.

    Akhbari M, Babaei F, Navidi-Moghaddam A, Ghafghazi S, Khodabandehloo F, Sarookhani MR, Dargahi L, Mohammadi G… · 2026-06-15

    unreviewed
  3. 3
    Pulmonary and cerebral damage in COVID-19 survivors: is there any association?

    Arrigoni A, Capelli S, Imeri G, Pennati F, Venturelli S, Bonaffini PA, Sanvito F, Marra P, Aliverti A, Di Mar… · 2026-06-17

    open access unreviewed
  4. 4
    The effect of probiotic and synbiotic supplementation on sleep parameters in exercised population: a systematic review and synthesis without meta-analysis (SWiM) of randomized controlled trials.

    Salehi Asl M, Ahmadi F, Ershadmanesh M, Mortezapour E, Torki F, Danandeh A, Dehghani E, Danandeh K. · 2026-05-25

    open access unreviewed
  5. 5
    Ceftriaxone for methicillin-susceptible <i>Staphylococcus aureus</i> bloodstream infections is associated with increased short-term mortality: a systematic review and meta-analysis.

    Maraolo AE, Nobile M, Gentile I. · 2026-05-11

    open access unreviewed
  6. 6
    Arginine deprivation induces prolonged autophagy activation and ROS-dependent cell death in glioblastoma multiforme.

    Abdelkhalek M, El-Jawhari Y, Shaheen M, Saad R, Sarieddine M, El-Husseini N, El-Sibai M, Abi-Habib RJ. · 2026-05-07

    open access unreviewed
  7. 7
    Diabetic cerebral microvascular disorder: from key pathologies to targeted interventions.

    Zhang Q, Liu J, Ji X. · 2026-04-27

    open access unreviewed
  8. 8
    The duodenal microbiota is compartmentalized and clinically stable yet rapidly responsive to nutrient exposure.

    Wyss J, Baehler S, Ferracini J, Kroell D, Rossier AM, Krupka N, Misselwitz B, Yilmaz B, Wiest R. · 2026-04-18

    open access unreviewed
  9. 9
    Spatial mapping of human colonic niches reveals rapid, mucus-specific microbiota disruption after bowel cleansing.

    Yilmaz B, Moulin S, Heimgartner B, Li H, Geuking M, Juillerat P, Misselwitz B, Macpherson AJ, Wiest R. · 2026-02-25

    open access unreviewed
  10. 10
    Research progress on biological functions of astragalus stems and leaves and their application in cattle production: a review.

    Ma C, Zhang J, Yang Q, Zhang Q. · 2026-02-24

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.