Argininosuccinate lyase (ASL)
Clinical / pharmacological. Argininosuccinic aciduria
What it does, reaction by reaction
Urea Cycle Amino Acid & Nitrogen Metabolism · Mitochondrial matrix + cytosol
Argininosuccinate → L-arginine + fumarate
Converts Argininosuccinate into Arginine Fumarate
› Notes
Cytosolic argininosuccinate lyase (ASL) cleaves argininosuccinate without a required redox cofactor. Fumarate enters the aspartate–argininosuccinate shunt, where it can be converted through malate and oxaloacetate to aspartate, linking the cycle to the tricarboxylic acid cycle.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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