Aminotransferases + glutamate dehydrogenase (PLP-dependent nitrogen removal)
Cofactors used
Clinical / pharmacological. Activating mutations: hyperinsulinism-hyperammonaemia syndrome
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Amino acid + α-ketoglutarate ⇌ corresponding α-keto acid + glutamate
Converts Alpha-ketoglutarate into Glutamate
› Notes
A PLP-dependent aminotransferase commonly initiates catabolism of amino acids whose nitrogen is handled by transamination. The reaction is reversible; glutamate subsequently supplies ammonia through GDH or supplies aspartate for urea synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Metabolic regulation of oocyte maturation and early embryo development in mammals.
Rong S, Fu Y, Li Y, Jiang YC, Chen L, Zhao Y, Zhu W, Mu L. · 2026-08-06
open access unreviewed -
2
Decoding osteosarcoma pathogenesis: the pivotal influence of m<sup>6</sup>A modification.
Huang C, Han Z, Su J, Zhang M, Lin Y, He H, Tang Y, Guo P, Wang Y, Chen H. · 2026-07-21
open access unreviewed -
3
Therapeutic strategies of metabolic reprogramming in non-small cell lung carcinoma.
Liu J, Qian F. · 2026-04-15
cited 2× unreviewed -
4
The Maintenance of Dysmyelinated Small-Diameter Axons by 14-3-3s in the Central Nervous System.
Yamada N, Saito H, Takahashi R, Fujisato M, Hosoda Y, Sasaki B, Yamada M, Abe S, Hayashi C, Yoshimoto A, Ohka… · 2026-11-01
open access unreviewed -
5
Research progress in metabolic reprogramming and targeting metabolic pathways for clear cell renal cell carcinoma.
Yao JT, Hu PC, Li XW, Xu JC, Wang KJ, Ye SZ, Meng XY, Chen HC, Liang Y, Ma Q. · 2025-12-19
open access unreviewed -
6
Toward targeted therapeutics for lobular breast cancer.
Fanucci KA, Bahnassy S, Roy AM, Sokolova A, Stover DG, Simpson PT, Riggins RB, Jeselsohn R. · 2026-10-01
open access unreviewed -
7
Posttranslational Modifications of p62/SQSTM1 in Health and Disease.
Wang W, Jiang X, Qiu R, Wijaya CS, Chen M, Wang J, Zhu L, Jin H, Feng L. · 2026-09-30
open access unreviewed -
8
Traumatic brain injury induces cell-type-specific remodelling of the proteostasis network.
Lefkowitz J, Taylor M, Kumar A, Jha RM, Rajasundaram D, Ciryam P. · 2026-10-01
open access unreviewed -
9
Glutamine Metabolism in Health and Diseases.
Ding Y, Tong F, Zeng J, Cui CP. · 2026-09-29
open access unreviewed -
10
Nicotinamide nucleotide transhydrogenase directly couples redox homeostasis to proline biosynthesis in human glioma.
Vettore LA, Boufersaoui A, Lyu Y, Oudin A, Abbott KL, Subudhi S, Gültekin Y, Eales KL, Rajgopal I, Escribano-… · 2026-08-21
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.