Aminotransferases + glutamate dehydrogenase (PLP-dependent nitrogen removal)
Cofactors used
Clinical / pharmacological. Activating mutations: hyperinsulinism-hyperammonaemia syndrome
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Amino acid + α-ketoglutarate ⇌ corresponding α-keto acid + glutamate
Converts Alpha-ketoglutarate into Glutamate
› Notes
A PLP-dependent aminotransferase commonly initiates catabolism of amino acids whose nitrogen is handled by transamination. The reaction is reversible; glutamate subsequently supplies ammonia through GDH or supplies aspartate for urea synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Therapeutic strategies of metabolic reprogramming in non-small cell lung carcinoma.
Liu J, Qian F. · 2026-04-15
unreviewed - 2
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3
Hypoxia drives ferroptosis resistance and immunosuppression in hepatocellular carcinoma by inducing UBASH3B-mediated glutamine metabolism reprogramming and CXCL8 expression.
Pan GQ, Zhang SP, Wang X, Qu Y, Liu XF, Yan YC, Li T, Dong ZR. · 2026-08-06
unreviewed -
4
GLUD1 Inhibition Disrupts Glutamate Homeostasis and Induces Metabolic and Redox Stress in Gliomas.
Trybula M, Łysiak M, Wiechec E, Malmström A, Söderkvist P. · 2026-08-03
unreviewed -
5
Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.
Ahmad R, Zobel G, Hannaford R, Maclean P, Olson T, Hurst C, Bracegirdle J, Young W, Rettedal E, Anderson RC, … · 2026-06-08
open access unreviewed -
6
A malignant symbiosis: The neuro-metabolic symphony rewires the tumor microenvironment.
Zhang Z, Jia Y, Liu T, Wang S, Liu L. · 2026-06-08
open access unreviewed -
7
Fingerprinting the Metabolic and Lipidomic Landscapes of Pancreatic Ductal Adenocarcinoma with MALDI Imaging.
Yousf S, Glunde K, Brown DR, Tressler C, Solaiyappan M, Krishnamachary B, Mironchik Y, Dbouk M, Goggins MG, B… · 2026-08-01
unreviewed -
8
Calcitonin Gene-Related Peptide (CGRP)-Containing Terminals in the Central Amygdala of Mice and Monkeys: Ultrastructural Analysis and Subsynaptic Expression of GluD1.
Choi D, Villalba RM, Dalal K, Paré JF, Dravid SM, Smith Y. · 2026-07-01
unreviewed -
9
Multi-Omics Integration Uncovers That Tenofovir Disoproxil Fumarate Is Linked to Hepatic Metabolic Reprogramming Independent of Viral Infection
· 2026-06-01
open access unreviewed -
10
Clinical Report and Genetic Analysis of a Patient With Congenital Hyperinsulinism Hyperammonemia Caused by a Novel Missense Mutation in the Structural Domain of the Isoform of the GLUD1 Gene.
Li T, Liu T, Li L, Liu Y, Zhang Q, Cheng X, Li Z. · 2026-06-18
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.