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rate-limiting unreviewed

Aldolase B (fructose-1-phosphate aldolase)

1 reactions · 1 pathways

Clinical / pharmacological. Hereditary fructose intolerance: hypoglycaemia, vomiting after fructose/sucrose

What it does, reaction by reaction

1 reactions

Fructose Metabolism (Fructolysis) Carbohydrate Metabolism · Cytosol

step 2 Irreversible/directional

Fructose-1-phosphate → dihydroxyacetone phosphate + glyceraldehyde

Converts Fructose-1-phosphate into Dihydroxyacetone phosphate Glyceraldehyde

› Notes

Aldolase B (fructose-1-phosphate aldolase) cleaves fructose-1-phosphate without a redox cofactor. This is the defining hepatic fructolysis cleavage reaction and is functionally the pathway's critical/committed processing step because failure traps phosphate as fructose-1-phosphate.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Fructose Metabolism (Fructolysis)

Listed there as: Aldolase B

Accelerated by

Substrate availability

Inhibited by

Product accumulation; loss of activity causes fructose-1-phosphate trapping

Hormonal control

No major acute hormonal control

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.

    Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28

    open access unreviewed
  2. 2
    Tissue-specific transcriptomic responses and skeletal-muscle ultrastructural observations in Semah mahseer (<i>Tor douronensis</i>) under acute thermal and hypoxic conditions.

    Uchuwittayakul A, Phuthong W, Kong C, Rajitdumrong C, Adisornprasert Y, Kumwan B, Meachasompop P, Ely SSP, Va… · 2026-08-22

    open access unreviewed
  3. 3
    Vaccine diluent affects expression levels of immune related genes in caecal tonsils of layer chickens vaccinated with live attenuated <i>Salmonella</i> Typhimurium vaccine.

    Khan S, McWhorter AR, Andrews DM, Underwood GJ, Chousalkar KK. · 2026-07-19

    open access unreviewed
  4. 4
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  5. 5
    Proliferation and differentiation in intestinal organoids are balanced by ligand-modulated EGFR trafficking.

    Caracci MO, Seidler S, Muñoz-Nava LM, Soetje B, Michel K, Bastiaens PI. · 2026-08-27

    cited 1× open access unreviewed
  6. 6
    Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.

    Li M, Huang C, Yu S. · 2026-07-02

    open access unreviewed
  7. 7
    Co-transplantation of pancreatic islets with adipose-derived mesenchymal stem cells in vascularized kidney ECM scaffolds to restore type 1 diabetes mellitus.

    Choi M, Shanto PC, Fahad MAA, Bae SH, Lee BT. · 2026-06-04

    open access unreviewed
  8. 8
    Full-length transcriptomic profiling of chicken liver metabolism under different feeding states using nanopore sequencing.

    Xu B, Wang H, Shu X, Liu L, Wang Y, Li Y, Niu Z, Chen Z, Zheng X, Chen J. · 2026-07-02

    open access unreviewed
  9. 9
    [Hepatocellular carcinoma-derived lactate-mediated histone H3K18 lactylation modifies S100A2 transcription to promote proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells].

    Huang L, Shao Y, Zhou W, He J. · 2026-09-01

    unreviewed
  10. 10
    Experimental model of ventilator-induced lung injury induces proteomic signatures of neurodegeneration in the hippocampus.

    Winzey KD, Guzman S, Yang E, Moreira D, Wang X, Gu X, Dillon ST, Ely EW, Karumanchi SA, Libermann TA, Lahiri … · 2026-09-29

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.