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rate-limiting unreviewed

Aldolase B (fructose-1-phosphate aldolase)

1 reactions · 1 pathways

Clinical / pharmacological. Hereditary fructose intolerance: hypoglycaemia, vomiting after fructose/sucrose

What it does, reaction by reaction

1 reactions

Fructose Metabolism (Fructolysis) Carbohydrate Metabolism · Cytosol

step 2 Irreversible/directional

Fructose-1-phosphate → dihydroxyacetone phosphate + glyceraldehyde

Converts Fructose-1-phosphate into Dihydroxyacetone phosphate Glyceraldehyde

› Notes

Aldolase B (fructose-1-phosphate aldolase) cleaves fructose-1-phosphate without a redox cofactor. This is the defining hepatic fructolysis cleavage reaction and is functionally the pathway's critical/committed processing step because failure traps phosphate as fructose-1-phosphate.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Fructose Metabolism (Fructolysis)

Listed there as: Aldolase B

Accelerated by

Substrate availability

Inhibited by

Product accumulation; loss of activity causes fructose-1-phosphate trapping

Hormonal control

No major acute hormonal control

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  2. 2
    Co-transplantation of pancreatic islets with adipose-derived mesenchymal stem cells in vascularized kidney ECM scaffolds to restore type 1 diabetes mellitus.

    Choi M, Shanto PC, Fahad MAA, Bae SH, Lee BT. · 2026-06-04

    open access unreviewed
  3. 3
    TERT drives liver tumorigenesis beyond telomere elongation.

    Braud L, Vernerey J, Guille A, Cordier P, Ginet C, Egger T, Bernabe M, Churikov D, Da Costa Q, Meghraoui A, D… · 2026-07-02

    unreviewed
  4. 4
    Single-cell transcriptomic insights into lipoprotein transport in yolk sac membrane endodermal epithelial cells of chicken embryos.

    Wu JC, Hu ZQ, Lin YY, Mersmann HJ, Ding ST. · 2026-04-17

    open access unreviewed
  5. 5
    Delayed diagnosis of hereditary fructose intolerance presenting as chronic lean steatosis in an adolescent.

    Hurlock A, Lah M, Hyaduck HS, Molleston JP, Jarasvaraparn C. · 2026-07-13

    unreviewed
  6. 6
    Endogenous fructose production in patients and mice with aldolase B deficiency.

    Buziau AM, Simons N, Tolan DR, Caiment F, Scheijen JLJM, van de Waarenburg MP, Schalkwijk CG, Brouwers MCGJ. · 2026-07-17

    unreviewed
  7. 7
    Deoxycorticosterone acetate-induced acceleration of embryogenesis and oxidative and metabolic stresses in zebrafish.

    Liu S, Wang K, Huang W, Zhang J, Han C, Li Q, Gong J. · 2025-10-28

    unreviewed
  8. 8
    Transcription Factor ATF4 Deletion Reprograms Glucose Metabolism in Clear Cell Renal Cell Carcinoma

    Chi Y, Chen Q, Mere Del Aguila E, Gross S, Wagner J, Reilly S, Nanus D, Gudas L. · 2026-06-01

    open access unreviewed
  9. 9
    Study on the Differences in Transcriptome and Metabolome of Pectoralis Major Muscles Between Jiangshan Black-Bone Chickens and Baier Buff Chickens

    Zhu L, Li S, Zhao A, Wang Z. · 2026-06-01

    open access unreviewed
  10. 10
    Single-Cell Transcriptomic Profiling Reveals Immunometabolic Reprogramming and Cell-Cell Communication in the Tumor Microenvironment of Human Hepatocellular Carcinoma

    Díaz-Campos M, Hernández-Lemus E. · 2026-06-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.