Aldolase B (fructose-1-phosphate aldolase)
Clinical / pharmacological. Hereditary fructose intolerance: hypoglycaemia, vomiting after fructose/sucrose
What it does, reaction by reaction
Fructose Metabolism (Fructolysis) Carbohydrate Metabolism · Cytosol
Fructose-1-phosphate → dihydroxyacetone phosphate + glyceraldehyde
Converts Fructose-1-phosphate into Dihydroxyacetone phosphate Glyceraldehyde
› Notes
Aldolase B (fructose-1-phosphate aldolase) cleaves fructose-1-phosphate without a redox cofactor. This is the defining hepatic fructolysis cleavage reaction and is functionally the pathway's critical/committed processing step because failure traps phosphate as fructose-1-phosphate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Fructose Metabolism (Fructolysis)
Listed there as: Aldolase B
Substrate availability
Product accumulation; loss of activity causes fructose-1-phosphate trapping
No major acute hormonal control
Recent literature
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