DHODH
What it does, reaction by reaction
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP)
Dihydroorotate availability and an oxidized mitochondrial CoQ pool
Leflunomide/teriflunomide, brequinar
No principal direct hormonal control; respiration and proliferative state influence flux.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
2
IGF2BP3 promotes gastric cancer progression by inhibiting ferroptosis through ETV4-mediated regulation of GCH1.
Li K, Wei H, Li F, Zheng Y, Zhou Y. · 2026-05-01
open access unreviewed -
3
PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators.
Periyasamy S, Jarrett T, Truong J, Skouta R. · 2026-03-26
open access unreviewed -
4
FDA-approved IMPDH inhibitors synergize with ribavirin to inhibit respiratory syncytial virus by interfering with purine <i>de novo</i> synthesis.
Hu H, Wang Q, Ai Q, Zhou P, He Y, Ye Z, Ma K, Zhou M, Huang S, Wang L, Qi N, Xiao G, Wang S. · 2026-03-17
cited 2× open access unreviewed -
5
Antitumor activity and structure-activity relationship of poly (ADP-ribose) polymerase (PARP)-based dual inhibitors.
Yang C, Shang Y, Li X, Li J, Li H, Han J. · 2025-12-15
open access unreviewed -
6
Ubiquitination-dependent regulation of ferroptosis in ischemic heart and brain.
Zhang YY, Long XY, Tian J, Luo XJ, Peng J. · 2026-06-08
open access unreviewed -
7
Ferroptosis and prostate cancer: A translational path from molecular mechanisms to precision therapy.
Huang Y, Ma Y, He J, Song T. · 2025-12-08
open access unreviewed -
8
Contribution of dihydroorotate dehydrogenase complex to NADH supply and metabolic flux redirection in Clostridium acetobutylicum.
Jiang D, Yi J, Zhu H, Gao L, Wang S, Liu G, Li L, Zhang Q, Wang M, Ehrenheich A, Li F, Xiao Y, Liu Z, Zhang K. · 2026-05-25
unreviewed -
9
Targeting dihydroorotate dehydrogenase (hDHODH) beyond the barrier: discovery of MEDS700 as blood-brain barrier permeable hDHODH inhibitor.
Sainas S, Vigato C, Circosta P, Zonfrillo M, Servidei T, Alberti M, Rescigno M, Miggiano R, Gaidano V, Vitale… · 2026-04-27
unreviewed -
10
Novel noscapine derivative induces AML differentiation by dual-engaging DHODH and mitochondrial lipids to trigger a metabolic-epigenetic-transcriptional cascade.
Shen S, Li D, Zhang Y, Li S, Li L, Shen W, Ma Y, Zhang W, Tao R, Wang W, Jiang B, Bai F, Liu C, Zhang Y, Yin … · 2026-05-22
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.