unreviewed
Renal urate transport (URAT1/GLUT9; not an enzyme)
0 reactions · 0 pathways
What it does, reaction by reaction
0 reactions
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
1 entries
Purine Degradation (to Uric Acid)
Accelerated by
Volume depletion and organic anion exchange can favor urate reabsorption
Inhibited by
Uricosuric drugs such as probenecid/lesinurad inhibit relevant transport
Hormonal control
Insulin resistance and hyperinsulinemia are associated with increased renal urate reabsorption.
Recent literature
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