HGPRT
What it does, reaction by reaction
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Purine Salvage Pathway
Availability of hypoxanthine/guanine and PRPP
Product inhibition by IMP/GMP; low PRPP limits flux
No important acute hormonal regulation; constitutive activity is critical in neural tissue.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Redundant mispair excision mechanisms in eukaryotic DNA mismatch repair.
Putnam CD, Kolodner RD. · 2026-10-04
open access unreviewed -
2
Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase.
E Silva IR, Mantovani M, Lino MESD, Albuquerque AO, da Silva JHM, Nagem RAP, Rojas AL, Sartori GR, Horjales E… · 2026-06-08
open access unreviewed -
3
Machine learning and computational approaches to model therapeutic response and resistance in diffuse midline glioma.
Dubois OA, Loughnan OEL, Jiang Y, Petraello B, Douglas AM, McLachlan T, Findlay IJ, Vo T, Savary C, Dun MD. · 2026-09-29
open access unreviewed -
4
Nuclear proteome analysis suggests spatial and temporal compartmentalization of metabolic enzymes during Trypanosoma cruzi cell cycle.
Menezes AP, Gachet-Castro C, McGill S, Burchmore R, Silber A, Elias MC, da Cunha JPC. · 2026-09-28
open access unreviewed -
5
Saponins Derived from Chinese Medicinal Materials in Hyperuricemia and Gout: Therapeutic Mechanisms and Emerging Perspectives.
Wang Z, Chen Y, Li T, Hu Y, Li L. · 2026-09-20
open access unreviewed -
6
Rethinking Left Ventricular Noncompaction and Excessive Left Ventricular Trabeculation: Development, Genetics, and a Proposed Conceptual Framework.
Hirono K. · 2026-09-15
open access unreviewed -
7
Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis.
Hall B, Ebrahim YM, Sharpe JL, Makhija S, Ellis BCS, Wong KE, Walker H, Yagüe-Capilla M, Timmons HO, Bradley … · 2026-09-16
open access unreviewed -
8
Primary Headache Disorders in Pediatric Irritable Bowel Syndrome: Characterizing IBS-Associated Migraine Highlights.
Akıncı Göktaş Ö, Selbuz S. · 2026-09-11
open access unreviewed -
9
Integrating spatial phytochemistry and metabolomics reveals the spatial chemical organization of Gymnadenia conopsea and its pharmacological effects in kidney-yang deficiency syndrome.
Lan T, Zhang X, Zhang X, Cai D, Zhou Z, Jin H, Wang Z. · 2026-09-09
unreviewed -
10
Causes of Death Among Stillbirths and Children Aged <5 Years in Africa and South Asia - Child Health and Mortality Prevention Surveillance, Seven Countries, 2016-2024.
Madewell ZJ, Dangor Z, Mutevedzi PC, Johnstone SL, Lala SG, Madhi SA, Velaphi S, Assefa N, Kebede M, Madrid L… · 2026-09-10
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.