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unreviewed

Adenylosuccinate lyase (ADSL)

2 reactions · 1 pathways

What it does, reaction by reaction

2 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 9 Irreversible/directional

SAICAR → 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)

Converts SAICAR into AICAR

› Notes

Adenylosuccinate lyase catalyzes SAICAR → AICAR + fumarate. This nonhydrolytic elimination releases the aspartate carbon skeleton as fumarate, linking purine synthesis to the tricarboxylic acid cycle.

step 13 Irreversible/directional

Adenylosuccinate → AMP

Converts Adenylosuccinate into AMP

› Notes

Adenylosuccinate lyase catalyzes adenylosuccinate → AMP + fumarate. The reaction completes AMP synthesis and again releases the aspartate carbon skeleton as fumarate.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects.

    Zhang L, Fan Y, Shi W, Zhou X. · 2026-07-16

    open access unreviewed
  2. 2
    Ancient DNA and Human Physiology.

    Bayarsaikhan M, Boyle MJ, Demers PV, Habeck EW, Romeyer-Dherbey JH, Silverman S, Massilani D. · 2026-03-06

    unreviewed
  3. 3
    A Chopper Amplifier with Feedforward SAR ADC Assisted DC Servo Loop Achieving ±1V DC Offset Cancellation in 2.1s for Neural Signal Recordings.

    Huang B, Hao Y, Wu J, Wang Y, Sun A, Zhang J, Zhao Y, Zhang H. · 2026-10-01

    unreviewed
  4. 4
    PROMETEO: Infrastructure Remote-Control and Geophysical Monitoring System of the INGV Osservatorio Vesuviano.

    Benincasa A, Caputo A, Liguoro F, Scarpato G, Orazi M, Manzo R. · 2026-09-18

    open access unreviewed
  5. 5
    Identification of key genes and mechanistic exploration of metabolic reprogramming in osteoporosis.

    He Y, Shi C, Yu X, Wang A. · 2026-09-28

    unreviewed
  6. 6
    Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis.

    Hall B, Ebrahim YM, Sharpe JL, Makhija S, Ellis BCS, Wong KE, Walker H, Yagüe-Capilla M, Timmons HO, Bradley … · 2026-09-16

    open access unreviewed
  7. 7
    Telerehabilitation for Motor Recovery in Adults with Neurological Disorders: A Systematic Review and Meta-Analysis Across Motor Domains, Delivery Models, and Follow-Up Effects.

    Calabrò RS, D'Souza AF, Pournajaf S, Baglio F, Leochico CFD, Kalron A. · 2026-09-14

    open access unreviewed
  8. 8
    Acyl carrier protein is essential for apicoplast biogenesis in malaria parasites independent of fatty acid synthesis.

    Geher SWR, Falekun S, Pita-Aquino JN, Swift RP, Okada M, Jami-Alahmadi Y, Wohlschlegel JA, Prigge ST, Sigala … · 2026-09-14

    open access unreviewed
  9. 9
    Metabolic regulation of calcium homeostasis via SERCA succination.

    Ham SJ, Kim Y, Kim S, Bang S, Koh YH, Roh SH, Park HS, Chung J. · 2026-09-09

    open access unreviewed
  10. 10
    Severe adenylosuccinate lyase deficiency with early autonomic dysfunction: functional characterization of a novel ADSL variant and exploratory treatment with disulfiram.

    Kravljanac R, Zikanova M, Milačić I, Tadić BV, Popović S, Oparnica V, Skopova V, Forejtova A, Baresova V. · 2026-06-15

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.