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unreviewed

Adenylosuccinate lyase (ADSL)

2 reactions · 1 pathways

What it does, reaction by reaction

2 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 9 Irreversible/directional

SAICAR → 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)

Converts SAICAR into AICAR

› Notes

Adenylosuccinate lyase catalyzes SAICAR → AICAR + fumarate. This nonhydrolytic elimination releases the aspartate carbon skeleton as fumarate, linking purine synthesis to the tricarboxylic acid cycle.

step 13 Irreversible/directional

Adenylosuccinate → AMP

Converts Adenylosuccinate into AMP

› Notes

Adenylosuccinate lyase catalyzes adenylosuccinate → AMP + fumarate. The reaction completes AMP synthesis and again releases the aspartate carbon skeleton as fumarate.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (<i>Carassius gibelio</i>, CAS V).

    Wang Y, Zhang Y, Wu L, Li C, Chen Q, Han D, Liu H, Zhang Z, Xie S, Jin J. · 2026-04-03

    open access unreviewed
  2. 2
    A novel homozygous variant causing fatal neonatal adenylosuccinate lyase (ADSL) deficiency presenting with respiratory failure and encephalopathy.

    Wolfe K, Armstrong L, Wambach C, Leon E, Ohrtman K, Miller I, Pyle T, Schroeder J, Fraser J, Kousa Y. · 2026-08-11

    unreviewed
  3. 3
    ADSL drives fumarate mediated scrib-rictor complex formation to promote metastasis dissemination in triple-negative breast cancer.

    Fan Y, He X, Deng W, Sun J, Qin J, Zou Y, Zhu X, Xie X, Tang H, Yu P, Bao W, Ye F. · 2026-07-20

    unreviewed
  4. 4
    Alpha-lipoic acid attenuates valproic acid-induced autism-like phenotypes in zebrafish by enhancing antioxidant capacity and repressing oxidative stress, inflammation, apoptosis, and HPI-axis signaling.

    Li Z, Wang J, Feng T, Lu W. · 2026-03-19

    unreviewed
  5. 5
    Severe adenylosuccinate lyase deficiency with early autonomic dysfunction: functional characterization of a novel ADSL variant and exploratory treatment with disulfiram.

    Kravljanac R, Zikanova M, Milačić I, Tadić BV, Popović S, Oparnica V, Skopova V, Forejtova A, Baresova V. · 2026-06-15

    unreviewed
  6. 6
    A Chopper Amplifier with Feedforward SAR ADC Assisted DC Servo Loop Achieving ±1V DC Offset Cancellation in 2.1s for Neural Signal Recordings.

    Huang B, Hao Y, Wu J, Wang Y, Sun A, Zhang J, Zhao Y, Zhang H. · 2026-06-29

    unreviewed
  7. 7
    Vigabatrin-Associated Brain Abnormalities on MRI in a Patient with PCDH19-Clustering Epilepsy

    Apanasenko O, Głodek-Brzozowska E, Guz P, Łobodzińska A, Perenc L. · 2026-06-01

    open access unreviewed
  8. 8
    Environmental Pollutant PCB 153 Is Associated with Candidate Alternative Splicing Alterations in Intellectual Disability-Associated Genes: An Exploratory RNA-Seq Splicing Analysis in a Neuronal Model

    Lui M, Minuti A, D’Angiolini S, Scuruchi M, Silvestro S, Artimagnella O. · 2026-06-01

    open access unreviewed
  9. 9
    Arthrogryposis Multiplex Congenita: Comprehensive Review from a Neuromuscular Standpoint

    Seneor D, Barile J, Mendes P, Orsini M, da Silva E, Farias I, Serrano P, Pinto W, Oliveira A, de Souza P. · 2026-06-01

    open access unreviewed
  10. 10
    Gene-edited live-attenuated vaccines against Toxoplasma gondii: recent advances and future frontiers.

    Sang X, Zhang H, Zhang Y, Jin Y, Sun F, Feng Y, Al-Olayan E, Yang N, El-Ashram S. · 2026-06-07

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.