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unreviewed

PRPP synthetase

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

2 entries

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP)

Accelerated by

Inorganic phosphate; increased ribose 5-phosphate availability

Inhibited by

ADP, GDP, and other purine ribonucleotides

Hormonal control

No dominant acute hormonal switch; insulin and carbohydrate availability can increase pentose phosphate pathway flux and PRPP supply indirectly.

Purine Salvage Pathway

Accelerated by

Inorganic phosphate; ribose 5-phosphate availability

Inhibited by

ADP, GDP, purine nucleotide feedback

Hormonal control

Indirectly increased by insulin-supported carbohydrate metabolism; no defining direct hormonal allostery.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Neuronal Prps is required for synaptic development and locomotor function in Drosophila melanogaster.

    Dang TN, Yoshida H. · 2026-08-17

    unreviewed
  2. 2
    Enhanced production of l-histidine in <i>Escherichia coli</i> through systematic metabolic engineering and CER controlled fermentation.

    Zhang B, Liu X, Zhao T, Hao J, Wang Z, Xia M, Chen N, Wang X, Fan X. · 2026-05-25

    open access unreviewed
  3. 3
    Proteomic Signatures of Noise-Induced Hearing Loss in the Mouse Cochlea.

    Batissoco AC, Alencar-Coutinho D, Ferreira-Scatone AC, Diogo-Cavassana S, Oiticica J, Lezirovitz K, Bento RF. · 2026-10-01

    open access unreviewed
  4. 4
    Effects of N-carbamylglutamate on down yield and quality and thyroid transcriptome in breeding Huoyan geese.

    Wang M, Sun M, Han D, Lei S, Xu H, Peng X, Wang C, Ma W. · 2026-06-10

    open access unreviewed
  5. 5
    PACS1 syndrome variant alters the proteomic landscape of developing cortical organoids

    Gomez-Maqueo X, Rylaarsdam L, Woo A, Schroder A, Rakotomamonjy J, Bossert C, Smith T, Ruiz S, Gilardi J, Klei… · 2026-09-24

    open access unreviewed
  6. 6
    Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase.

    Ko CW, Shin D, Park J, Huh J, Kim Y, Park JW. · 2026-09-30

    open access unreviewed
  7. 7
    The Role of Pyrophosphate in the Origin of Life: An Energy-Based Hypothesis.

    Villa-Bellosta R. · 2026-09-09

    open access unreviewed
  8. 8
    Increased Risk of Gout among Patients with Trisomy 21: Insights from a Population-Based Study of over 30,000 Patients with Trisomy 21.

    Abdelmaksoud A, Igoe A, AbdAlnaeem MA, Toraih EA, Roller BA, Kaelber KL, Kaelber DC. · 2026-06-16

    open access unreviewed
  9. 9
    The molecular basis of ADP-ribose pyrophosphorylation by a phage PRPS-like enzyme in NAD+ reconstitution.

    Liu M, Ma J, Zhang Q, Xu S, Chen J, Lin E, Wu Y, Li H, Zhou B, Chen L. · 2026-09-01

    open access unreviewed
  10. 10
    From COPD and asthma to lung cancer: potential candidate genes and their associated biological pathways for the incidence risk of lung cancer.

    Arabfard M, Azimzadeh Jamalkandi S, Nobakht M Gh BF. · 2026-07-28

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.