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unreviewed

PRPP synthetase

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

2 entries

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP)

Accelerated by

Inorganic phosphate; increased ribose 5-phosphate availability

Inhibited by

ADP, GDP, and other purine ribonucleotides

Hormonal control

No dominant acute hormonal switch; insulin and carbohydrate availability can increase pentose phosphate pathway flux and PRPP supply indirectly.

Purine Salvage Pathway

Accelerated by

Inorganic phosphate; ribose 5-phosphate availability

Inhibited by

ADP, GDP, purine nucleotide feedback

Hormonal control

Indirectly increased by insulin-supported carbohydrate metabolism; no defining direct hormonal allostery.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Acquired thiopurine resistance and mismatch repair aberrations in paediatric B-cell acute lymphoblastic leukaemia relapse: A real-world data integrating mutational signatures, clones and clinical thiopurine dosing patterns.

    Bhatia P, Sharun S, Palla S, Brady SW, Kirubanandhan S, Ansari S, Singh M, Sreedharanunni S, Das A, Trehan A. · 2026-05-26

    unreviewed
  2. 2
    Broadening the phenotypic and molecular spectrum of PRS deficiency in females.

    Braid T, Scholten S, Yoganathan S, Alsalamah AK, Deschênes D, Deslongchamps G, Goobie S, Heon E, Tein I, Desh… · 2026-04-01

    open access unreviewed
  3. 3
    The Interplay of Splicing and Metabolism in Cancer.

    Voss DM, Cui Y, Klein PS. · 2026-06-20

    cited 1× open access unreviewed
  4. 4
    Ammonia storm: unmasking a suspected rare proximal urea cycle disorder in adulthood.

    Vikhe V, Shaik MH, Khaire P, Patil R, Chakraborty A. · 2026-06-12

    unreviewed
  5. 5
    Proteome-wide quantification of inositol pyrophosphate-protein interactions.

    Richter A, Isern JA, Ruwolt M, Lampe S, Majumdar A, Liu F, Furkert D, Fiedler D. · 2026-06-04

    open access unreviewed
  6. 6
    Hyperammonemia associated with low doses and concentrations of valproic acid in older adults with neurocognitive disorder.

    Coyne S, Das A. · 2026-06-02

    open access unreviewed
  7. 7
    Single-cell identifies and validates human circulating Treg subtype/state Treg<sup>fci</sup> in non-small cell lung cancer.

    Liu X, Liu Y, Duan W, Weng J, Dai H, Liu F, Wang L, Qian M, Zhu B, Wu S, Ye Y, Yuan M, Hong S, Wang M, Cheng … · 2026-06-03

    cited 1× open access unreviewed
  8. 8
    Integrating CRISPR genome editing with liver organoid and hiPSC-derived microfluidic platforms to model metabolic dysfunction-associated steatotic liver disease.

    Oluwasegun AK. · 2026-05-19

    open access unreviewed
  9. 9
    Uncovering metabolic reprogramming in ovarian and cervical cancers with multi-omics.

    Ge Y, Luo Y, Hao B, Zhou Y, Wu R, Liu H, Tang L, Li Y, Li Y, Gong S, Liu H. · 2026-04-22

    open access unreviewed
  10. 10
    Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion-dependent β-thalassaemia.

    Theocharaki K, Delicou S, Ntzoura-Kani A, Simantiris N, Politou M, Komninaka V, Samiotaki M, Zoidakis J, Anto… · 2026-04-09

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.