unreviewed
PRPP synthetase
0 reactions · 0 pathways
What it does, reaction by reaction
0 reactions
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
2 entries
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP)
Accelerated by
Inorganic phosphate; increased ribose 5-phosphate availability
Inhibited by
ADP, GDP, and other purine ribonucleotides
Hormonal control
No dominant acute hormonal switch; insulin and carbohydrate availability can increase pentose phosphate pathway flux and PRPP supply indirectly.
Purine Salvage Pathway
Accelerated by
Inorganic phosphate; ribose 5-phosphate availability
Inhibited by
ADP, GDP, purine nucleotide feedback
Hormonal control
Indirectly increased by insulin-supported carbohydrate metabolism; no defining direct hormonal allostery.
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