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unreviewed

UGT1A1

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Heme Degradation (Bilirubin Pathway)

Accelerated by

Bilirubin availability; maturation/induction of hepatic expression

Inhibited by

UGT1A1 variants; some drugs that inhibit or compete for glucuronidation

Hormonal control

Developmental regulation is major; neonatal activity is low. Hormonal effects are indirect through hepatic maturation and cholestatic states

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Digeda-8 formula attenuates cholestatic liver injury in rats by restoring bile acid transport and suppressing inflammation: An integrated metabolomics and proteomics approach.

    Bayoude A, Yi R, Zhao Y, Runa A, Ming M, Hu S, Jirimu B. · 2026-06-24

    unreviewed
  2. 2
    <b>Gut bacterial</b> <i><b>O</b></i><b>-demethylation modulates systemic exposure to oral etoposide</b>.

    Tripathi A, Kyawt TE, Shin J, Won KJ, Armstrong AT, Ilktach G, Sullivan P, Weilbaker HA, Ko Y, Lee S, Lee W, … · 2026-02-13

    open access unreviewed
  3. 3
    Toxicity assessment of three emerging bisphenols (BPA, BPAP and BPC) and their binary mixtures in an advanced in vitro 3D HepG2 cell model.

    Štampar M, Ravnjak T, Štern A, Žegura B. · 2026-07-01

    unreviewed
  4. 4
    Structure-based machine learning model for discovering pregnane X receptor (PXR) agonists and biological activity validation.

    Huang FF, Luo Y, Chen H, Meng YH, Li W, Liang H, Ai CZ. · 2026-05-25

    unreviewed
  5. 5
    Role of pregnane X receptor in the upregulation of human aldehyde oxidase gene expression.

    Chen S, Mettu VS, Lau AJ. · 2026-05-23

    unreviewed
  6. 6
    Pharmacogenomic biomarkers in oncology: evidence, clinical utility, and barriers to implementation.

    Vishwash SK, Soni RB, Kosey S, Sood R. · 2026-08-06

    unreviewed
  7. 7
    Comparative efficacy and safety of first-line treatments for RAS wild-type metastatic colorectal cancer: A systematic review and network meta-analysis.

    Wu S, Wang C, Liu S. · 2026-06-03

    open access unreviewed
  8. 8
    Farnesoid X receptor and nuclear factor erythroid 2-related factor 2 synergistically ameliorate cholestatic liver injury by coordinating bile acid metabolism and transport.

    Zhou L, Liu Y, Gu Q, Du X, Liu F, Liu J, Xia C. · 2026-06-08

    unreviewed
  9. 9
    Enhancement of ursolic acid (UA), an active ingredient in hawthorn, on the uptake and metabolism of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) derived from Polygonum multiflorum.

    Li R, Ren S, Zhao Y, An N, Song J, Guan F, Ge J. · 2026-05-10

    unreviewed
  10. 10
    Early postoperative carbohydrate antigen 19-9 normalization drives prognosis after pancreatic ductal adenocarcinoma resection.

    Elemosho A, Chatzipanagiotou OP, Angez M, Baldo A, Mevawalla A, Alizai Q, Pawlik TM. · 2026-05-21

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.