unreviewed
UGT1A1
0 reactions · 0 pathways
What it does, reaction by reaction
0 reactions
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
1 entries
Heme Degradation (Bilirubin Pathway)
Accelerated by
Bilirubin availability; maturation/induction of hepatic expression
Inhibited by
UGT1A1 variants; some drugs that inhibit or compete for glucuronidation
Hormonal control
Developmental regulation is major; neonatal activity is low. Hormonal effects are indirect through hepatic maturation and cholestatic states
Recent literature
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