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unreviewed

Heme oxygenase-1 (HO-1)

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Heme Degradation (Bilirubin Pathway)

Accelerated by

Heme excess, oxidative stress, hypoxia, inflammatory stimuli

Inhibited by

Reduced heme substrate availability; pharmacologic metalloporphyrins can inhibit

Hormonal control

Stress/inflammatory transcriptional regulation predominates; no central acute endocrine switch

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    A transferrin receptor-targeted liposome for iron metabolism regulation-augmented photodynamic therapy in glioblastoma.

    Wen R, He G, Wan Y, Guo X, Xiong S, Wu Y, Wei Y, Li D, Lin J, Huang P. · 2026-09-16

    open access unreviewed
  2. 2
    Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.

    Zhang JY, Yang YQ, Zhang ZX, Jin JL, Luo ZY, Wang DY, Ruan CX, Dai TZ, Huang YL, Xu J, Shi JW, Li JY, Lei PF. · 2026-09-03

    open access unreviewed
  3. 3
    Rosmarinic acid-cerium nanocatalysts enable oxygenation-enhanced ROS neutralization and PET imaging-guided therapy for acute kidney injury.

    Zhao Y, Hao L, Hsu JC, Peng Y, Luo Z, Xiang S, Wang Y, Engle JW, Zhou X, Hu S, Liu P, Cai W. · 2026-08-05

    open access unreviewed
  4. 4
    Biomimetic nanoparticles camouflaged with M2 macrophage membrane for osteoporosis therapy: A triple-action strategy that upregulates anti-inflammation and osteogenic responses while suppressing MMP-9.

    Dai C, Chen C, Zhu J, Chao M, Yan H, Wei P, Guan M, Pan B, Gao F, Tang R. · 2026-09-18

    open access unreviewed
  5. 5
    Mentha-mediated selenium nanoparticles attenuate adriamycin-induced chronic kidney disease via multi-target modulation of oxidative, inflammatory, and fibrotic pathways.

    Abdelaziz AE, Shokeir AA, Awad BI, Awadalla A, Abdelghany AM, El-Khawaga OY. · 2026-09-16

    open access unreviewed
  6. 6
    Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.

    Kong D, Duan R, Wang X, Wang X, Zhao J. · 2026-09-18

    open access unreviewed
  7. 7
    Dietary taurine supplementation ameliorates growth performance, intestinal health, and environmental stress tolerance in summer-reared <i>Megalobrama amblycephala</i>.

    Chen K, Chen L, He Z, Xie P, Liu H, Gao Z, Wang H. · 2026-08-15

    open access unreviewed
  8. 8
    PET-MRI effects of N-acetylcysteine in patients with multiple sclerosis.

    Monti DA, Monadi SD, Mohamed FB, Alizadeh M, Zabrecky G, Wintering N, Gupta M, Steinmetz A, Kremens D, Bazzan… · 2026-08-18

    open access unreviewed
  9. 9
    An NIR-responsive FeS-loaded alginate hydrogel promotes diabetic wound healing through Nrf2 activation and macrophage polarization.

    Wang X, Chen J, Guo T, Yao H, Li N, Li Z, Li J. · 2026-08-21

    open access unreviewed
  10. 10
    Ferroptosis: significance to zoonotic diseases and therapeutic prospects.

    Tian L, Cheng X, Ni J, Yang R, Ouyang W, Qi T, Liu Q, Wang D, Chen H, Wang X. · 2026-08-25

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.