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unreviewed

Heme oxygenase-1 (HO-1)

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Heme Degradation (Bilirubin Pathway)

Accelerated by

Heme excess, oxidative stress, hypoxia, inflammatory stimuli

Inhibited by

Reduced heme substrate availability; pharmacologic metalloporphyrins can inhibit

Hormonal control

Stress/inflammatory transcriptional regulation predominates; no central acute endocrine switch

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Punicalagin alleviates senile osteoporosis by inhibiting the senescence of bone mesenchymal stem cells via NRF2/HO-1 pathway.

    Wang Y, Qin Y, Wang T, Zhang W, Chen K, Geng D, Yan Z, Xu Y, Lv S. · 2026-07-25

    unreviewed
  2. 2
    Ethnopharmacological potential and mechanistic study of Platycodon grandiflorum stems and leaves and Lonicera japonica stems and leaves against acute lung injury.

    Zhao N, Li H, Guo Y, Wu F, Wang X, Hua Y, Wei Y, Ji P, Ren J. · 2026-06-30

    unreviewed
  3. 3
    Evaluating the global cellular pharmacological effects of photodynamic therapy using label-free surface-enhanced Raman spectroscopy.

    Zhu Q, Zhou Q, Wang S, Yuan Y, Lu F. · 2026-06-07

    unreviewed
  4. 4
    The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart.

    Zhang Y, Xin Y, Zhou J, Yang G, Li S. · 2026-06-05

    open access unreviewed
  5. 5
    Roxadustat attenuates contrast-induced acute kidney injury potentially mediated via the Nrf2/HO-1 signaling pathway.

    Wang J, E JW, Zhang J. · 2026-05-20

    open access unreviewed
  6. 6
    Protective effects of <i>Angelica dahurica</i> polysaccharide on oxidative stress and liver injury induced by ovariectomized/D-galactose in rats.

    He XQ, Li YZ, Xu LB, Wu CF, Wei DD, Liu HY, Qiu F. · 2026-05-20

    open access unreviewed
  7. 7
    Magnetic nanohydroxyapatite-peptide silk fibroin hydrogel induces osteogenesis in canine periodontal ligament stem cells revealed by proteomic analysis.

    Purbantoro SD, Scatena M, Taephatthanasagon T, Rodprasert W, Somparn P, Nanthawong S, Makjaroen J, Jantaratan… · 2026-05-16

    open access unreviewed
  8. 8
    A review of the sirtuins family: pivotal regulators and emerging therapeutic targets in renal fibrosis.

    Deng Q, Li C, Luo J, Yin M, Qian S, Li L. · 2026-05-14

    open access unreviewed
  9. 9
    Ginsenoside Rg1 ameliorates renal ischemia-reperfusion injury by inhibiting FABP1-regulated Nrf2/HO-1 pathway.

    Chang X, Zhang L, Zheng G, Zhang H, Xue H, Feng W. · 2026-05-03

    open access unreviewed
  10. 10
    Parthenolide inhibits the progression of intrahepatic cholangiocarcinoma by promoting ferroptosis through inhibiting UBD.

    Xie Y, Wang J, Zhou J, Peng Y, Wang Y, Wang Y, Song Y. · 2026-04-28

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.