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unreviewed

ALAS2 (erythroid)

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Heme Biosynthesis (Porphyrin Pathway)

Accelerated by

Iron availability through 5′ iron-responsive element; erythropoietin-driven erythropoiesis

Inhibited by

Iron deficiency; heme excess

Hormonal control

Erythropoietin increases erythroid differentiation and ALAS2-associated heme synthesis

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Chlorpromazine induces hyposalivation by inhibiting muscarinic Ca<sup>2+</sup> signaling in salivary glands.

    Kim YJ, Kim YB, Kim S, Choi TY, Park HK, Choi SY. · 2025-07-23

    cited 1× open access unreviewed
  2. 2
    Molecular Mechanisms of Iron Metabolism and Overload.

    Tayal A, Kaur J, Sadeghi P, Maitta RW. · 2025-08-25

    cited 2× open access unreviewed
  3. 3
    The role of genetic testing in accurate diagnosis of X-linked sideroblastic anemia: novel ALAS2 mutations and the impact of X-chromosome inactivation.

    Jové-Solavera D, Rámila M, Ferrer-Cortés X, Olivella M, Venturi V, Morado M, Hernández-Rodríguez I, Khan A, P… · 2025-04-07

    cited 3× open access unreviewed
  4. 4
    Porphyrin overdrive rewires cancer cell metabolism.

    Adapa SR, Hunter GA, Amin NE, Marinescu C, Borsky A, Sagatys EM, Sebti SM, Reuther GW, Ferreira GC, Jiang RH. · 2024-04-22

    cited 16× open access unreviewed
  5. 5
    Major depression-related factor NEGR1 controls salivary secretion in mouse submandibular glands.

    Lee J, Kim S, Lee B, Kim YB, Kim KH, Chung G, Lee SJ, Lee S, Sun W, Park HK, Choi SY. · 2023-04-26

    cited 4× open access unreviewed
  6. 6
    Iron-dependent post transcriptional control of mitochondrial aconitase expression.

    Shen M, Goforth JB, Eisenstein RS. · 2023-01-01

    cited 14× unreviewed
  7. 7
    Epo-IGF1R cross talk expands stress-specific progenitors in regenerative erythropoiesis and myeloproliferative neoplasm.

    Hsieh HH, Yao H, Ma Y, Zhang Y, Xiao X, Stephens H, Wajahat N, Chung SS, Xu L, Xu J, Rampal RK, Huang LJ. · 2022-12-01

    cited 9× unreviewed
  8. 8
    Mammalian iron sulfur cluster biogenesis: From assembly to delivery to recipient proteins with a focus on novel targets of the chaperone and co-chaperone proteins.

    Maio N, Rouault TA. · 2022-01-25

    cited 13× unreviewed
  9. 9
    Implications of SARS-CoV-2 Infection in Systemic Juvenile Idiopathic Arthritis.

    Ailioaie LM, Ailioaie C, Litscher G. · 2022-04-12

    cited 11× open access unreviewed
  10. 10
    Heme Biosynthetic Gene Expression Analysis With dPCR in Erythropoietic Protoporphyria Patients.

    Granata F, Brancaleoni V, Barman-Aksözen J, Scopetti M, De Luca G, Fustinoni S, Motta I, Di Pierro E, Graziad… · 2022-07-18

    cited 6× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.