unreviewed
ALAS1 (hepatic)
0 reactions · 0 pathways
What it does, reaction by reaction
0 reactions
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
1 entries
Heme Biosynthesis (Porphyrin Pathway)
Accelerated by
Heme depletion; increased apo-cytochrome P450 demand; some drugs/xenobiotics
Inhibited by
Heme/hemin feedback; high carbohydrate/glucose suppresses induction
Hormonal control
Fasting and glucagon favor expression; carbohydrate/insulin suppresses ALAS1 induction; CYP-inducing drugs increase demand indirectly
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.
Correia MA, Sinclair PR, De Matteis F. · 2010-09-23
cited 61× unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.