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unreviewed

Cystathionine β-synthase (CBS)

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine)

Accelerated by

SAM allosterically activates; PLP sufficiency

Inhibited by

PLP deficiency; pathogenic CBS variants; low substrate

Hormonal control

Liver expression responds to dietary methionine/protein and catabolic state; no dominant rapid systemic hormone

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Significance of GSH and H<sub>2</sub>S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health.

    Majumder A, Majumder S, Bano S, Sen K, Nayak KB. · 2026-06-11

    open access unreviewed
  2. 2
    Albumin as a dynamic extracellular redox regulator: from Cys34 oxidation biomarkers to polysulfide-mediated homeostatic mechanisms and clinical applications.

    Ishima Y, Watanabe H, Ikeda-Imafuku M, Maeda H, Maruyama T, Otagiri M, Chuang VTG. · 2026-06-02

    open access unreviewed
  3. 3
    A review of the sirtuins family: pivotal regulators and emerging therapeutic targets in renal fibrosis.

    Deng Q, Li C, Luo J, Yin M, Qian S, Li L. · 2026-05-14

    open access unreviewed
  4. 4
    <i>Porphyromonas gingivalis</i> secreted factors drive epithelial-mesenchymal transition (EMT) through gingipains and an H<sub><b>2</b></sub>S-mediated bacterial defense system.

    Kazelnik M, Masri R, Caspi M, Wittenstein A, Tsarfaty I, Borenstein E, Caller T, Shatalin K, Nudler E, Rosin-… · 2026-03-24

    open access unreviewed
  5. 5
    Endogenous H₂S promotes HSPA8 sulfhydration to downregulate HIF1α and prevent ferroptosis in septic myocardial injury.

    Jiankui D, Zhang S, Li Z, Li W, Weina L, Miao W, Jian X, Changnan W. · 2026-02-09

    cited 1× open access unreviewed
  6. 6
    Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis.

    Guo L, Shi X, Wang G, Han W, Ding R, Wang S, Yuan D. · 2026-01-30

    open access unreviewed
  7. 7
    Riboflavin intake and kidney health: population evidence and mechanistic insights from NHANES and molecular docking analyses.

    Wu P, Long W, Xiao X, Wang L, Xu Y, Ma X. · 2026-01-25

    cited 1× open access unreviewed
  8. 8
    Insights into the Multifaceted Roles of 3-Mercaptopyruvate Sulfurtransferase in Liver Diseases.

    Xia Y, Li M. · 2026-06-25

    unreviewed
  9. 9
    Targeting cystathionine-β-synthase (CBS)-mediated cell stemness and gut microbiome homeostasis: mechanism and clinical study of combined resveratrol-curcumin treatment for ulcerative colitis.

    Su S, Ren L, Wang S, Zhang Z, Yang K, Zhou D, Wang M, Xi X, Zhong W. · 2026-07-21

    unreviewed
  10. 10
    Maternal methionine supplementation regulates skeletal muscle development through N<sup>6</sup>-methyladenosine mRNA methylation in broiler offspring.

    Gao M, Chen S, Chen Y, Han Q, Li D, Li W, Li X, Liu A, Nie W, Guo Y, Lv Z. · 2026-05-04

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.