unreviewed

SHMT

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

One-Carbon Metabolism (Folate Cycle)

Accelerated by

Serine and THF availability; PLP sufficiency

Inhibited by

PLP deficiency; product accumulation

Hormonal control

Growth and nutritional state alter expression and mitochondrial one-carbon flux indirectly

Recent literature

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Europe PMC · from cache · sorted by publication date

1
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12

open access unreviewed
2
YAP mediates activation of the serine synthesis pathway in the heart during pressure overload.
Hu C, Zhai P, Su X, Ramoszepeda J, Chiles E, Khatimah NG, Ikeda S, Kass DA, Sadoshima J. · 2026-06-05

unreviewed
3
Metabolomic and proteomic analysis reveals the metabolic changes of alkaloids in Ganoderma lucidum fermented tea.
Dai Y, Yue R, Chen J, Liu Y, Luo J, Fang S, Shen Q, Pan K, Zeng L. · 2026-04-26

unreviewed
4
Calibrating and documenting host-switching and evolution of incompatibility loci for two closely related Wolbachia clades.
Shropshire JD, Conner WR, Vanderpool D, Hoffmann AA, Turelli M, Cooper BS. · 2026-08-01

cited 1× unreviewed
5
Ischemic Stroke Increases Protein Expression of the Folate Receptor and One-carbon Enzymes in Brain Tissue From Male and Female Patients.
Burrows P, Dhillon H, McDemott GE, Covaleski A, Manfredi L, Beach TG, Serrano GE, Jadavji NM. · 2026-07-23

unreviewed
6
Nishida procedure versus single horizontal muscle transposition in monocular elevation deficiency.
Elhilali H, Awadein A, Soliman ME, Maher S. · 2026-07-16

unreviewed
7
Correction: Tumor suppressor function of SHMT in a Drosophila Ras<sup>V12</sup>Dlg<sup>RNAi</sup> model: DNA damage and synergistic gene-nutrient interaction with PLP.
Angioli C, Ferriero A, Pilesi E, Tesoriere G, Agostini B, Tramonti A, Contestabile R, Vernì F. · 2026-07-06

unreviewed
8
Comparative binding and activity analysis of known serine hydroxymethyltransferase inhibitors in biochemical assays.
Gräb J, Wagner C, Beber C, Szczesny J, Rubner S, Papasotiriou I. · 2026-07-02

unreviewed
9
Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple-Negative Breast Cancer.
Yang T, Qiu C, Li Y, Zhang Y, Wang C, Zhou J, Chu Z, Ma A, Huang L, Wong YK, Zhang J, Gao P, Liu C, Zhang J, … · 2026-06-30

unreviewed
10
Plasma serine and glycine in relation to clinical outcomes following neoadjuvant radiotherapy for rectal cancer.
Zwart NRK, Ueland PM, McCann A, McKay JA, Rütten H, Bogers JA, de Wilt JHW, Kampman E, Kok DE. · 2026-04-06

open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.