DHFR
What it does, reaction by reaction
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
One-Carbon Metabolism (Folate Cycle)
DHF accumulation and THF demand
Methotrexate; trimethoprim; pyrimethamine
No major acute hormonal regulation; expression rises with proliferative demand
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Phthalazine as a medically versatile polyheterocyclic core with underexplored anticancer potential.
Biegański M, Matysiak J, Szeliga M. · 2026-09-18
open access unreviewed -
2
HSV-1 metabolic hijacking: Mechanisms to precision therapeutics.
Kuang S, Zhang J, Chen J, He Z, Yang J, Li S, Ding J, Ma Z, Zhang B. · 2026-08-11
open access unreviewed -
3
Experimental and computational analysis of glycan processing at increased monoclonal antibody productivities.
Pranomphon R, Gialamoidou S, Yamabhai M, Sharfstein ST, Jiménez Del Val I. · 2026-07-20
open access unreviewed -
4
Live-attenuated <i>Toxoplasma gondii</i> RHΔ<i>ddx6</i> mutant establishes comprehensive immunity against acute, chronic, and congenital toxoplasmosis.
Yang Z, Wang J, Wu J, Fan Y, Ying T, Zhang H, Bai J, Wang Y, Liu P, Li G, Nie M, Tian X, Mei X, Zhang Z, Wang… · 2026-08-07
open access unreviewed -
5
Comprehensive safety assessment of novel dicholine folate vitamin.
Jonaitis T, Ulmann M, Wiesler G, Lukasik KV. · 2026-07-15
open access unreviewed -
6
Inflammation and carcinogenesis: molecular targets and small-molecule intervention strategies.
Lu WJ, Ojha R, Rana M, Gautam V, Li JY, Wang SA. · 2026-06-26
open access unreviewed -
7
Design, synthesis, and antibacterial activity study of pyrroloquinazoline diamine derivatives.
Cheng M, Tian Y, Shang J, He W, Zheng Y, Yan C, Chen X, Li J, Jiang Y, Fu Q, Deng X, Xiao X, Song M. · 2026-06-24
open access unreviewed -
8
MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.
Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N. · 2026-06-15
open access unreviewed -
9
Integration of nuclear mechanosensing with integrin-extracellular matrix adhesions.
Sandria S, King MC. · 2026-05-28
cited 1× open access unreviewed -
10
Comment on "sharp rise in high-virulence <i>Bordetella pertussis</i> with macrolides resistance in Northern China".
Li Z, Li Z, Ma X. · 2026-04-27
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.