DHFR
What it does, reaction by reaction
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
One-Carbon Metabolism (Folate Cycle)
DHF accumulation and THF demand
Methotrexate; trimethoprim; pyrimethamine
No major acute hormonal regulation; expression rises with proliferative demand
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Experimental and computational analysis of glycan processing at increased monoclonal antibody productivities.
Pranomphon R, Gialamoidou S, Yamabhai M, Sharfstein ST, Jiménez Del Val I. · 2026-07-20
unreviewed -
2
Design, synthesis, and antibacterial activity study of pyrroloquinazoline diamine derivatives.
Cheng M, Tian Y, Shang J, He W, Zheng Y, Yan C, Chen X, Li J, Jiang Y, Fu Q, Deng X, Xiao X, Song M. · 2026-06-24
open access unreviewed -
3
MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.
Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N. · 2026-06-15
open access unreviewed -
4
Integration of nuclear mechanosensing with integrin-extracellular matrix adhesions.
Sandria S, King MC. · 2026-05-28
open access unreviewed -
5
Comment on "sharp rise in high-virulence <i>Bordetella pertussis</i> with macrolides resistance in Northern China".
Li Z, Li Z, Ma X. · 2026-04-27
open access unreviewed -
6
<i>Toxoplasma gondii</i> effector GRA35 mediates neuronal damage <i>via</i> ER stress and mitochondria-associated apoptosis.
Wang J, Chen Y, Zhou N, Li F, Dai N, Chen Z, Liu S, An R, Chen L, Du J. · 2026-04-10
cited 1× open access unreviewed -
7
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12
open access unreviewed -
8
Exploring the gut microbiome and metabolomic interactions of antimetabolite drugs to optimize therapy.
Chen J, Wang Y, Xu L, Li X, Zhao L. · 2026-02-27
open access unreviewed -
9
Metabolomic profiling of neat uterine luminal fluid in cows: local enrichment and nutritional modulation.
Sagheer M, Hoorn QA, Maldonado MB, Schalich KM, Ashrafi N, A Mimi R, Graham SF, Selvaraj V, Hansen PJ. · 2026-01-07
cited 3× open access unreviewed -
10
In-vitro, in-vivo, and in-silico investigation of the traditionally used polyherbal combinations of Coptis teeta, Nyctanthes arbor-tristis, and Andrographis paniculata.
Tayeng D, Nath D, Sarma M, Roy D, Gogoi N, Chetia D, Zothantluanga JH. · 2026-06-11
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.