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unreviewed

MTHFR

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

One-Carbon Metabolism (Folate Cycle)

Accelerated by

S-adenosylmethionine deficiency/low methyl-group availability favors activity; FAD sufficiency

Inhibited by

S-adenosylmethionine allosterically inhibits; folate/riboflavin deficiency reduces activity

Hormonal control

Predominantly nutrient and allosteric regulation; insulin/growth signals influence one-carbon demand indirectly

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Molecular epidemiology of the MTHFR C677T polymorphism and its association with type 2 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital.

    Kassahun Berie G, Dagnaw M, Indracanti M, Dejen M, Berhane N. · 2026-03-16

    cited 1× unreviewed
  2. 2
    Interactions between nutrition and the epigenome: how can it be harnessed for public health?

    Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12

    open access unreviewed
  3. 3
    Premature coronary artery disease in women: sex-specific risk factors, pathogenetic mechanisms and clinical implications.

    Li F, Hong D, Yang M, Pang Z, Xi H, Zhang Q, Li C, Mo L, Peng L. · 2026-01-30

    open access unreviewed
  4. 4
    ICR-LAMP: A one-pot isothermal assay enabled by transient spatial separation and dynamic ICR for high-specificity SNP genotyping.

    Dong J, Shi J, Zhao J, Chen X, Zhan G, Du F, Cui X, Wang W, Ding S, Tang Z. · 2026-06-08

    unreviewed
  5. 5
    Physiological and transcriptomic insights deciphering cAMP-induced oxidative stress tolerance of antagonistic yeast Sporidiobolus pararoseus Y16.

    Zhao Y, Zhang X, Dhanasekaran S, Godana EA, Li J, Zhang Z, Zhao L, Zhang H. · 2026-05-20

    unreviewed
  6. 6
    Global DNA methylation and MTHFR gene polymorphism status of ghanaians with early-onset intracerebral hemorrhage: implications for future interventions.

    Opare-Addo PA, Sarfo FS, Ovbiagele B, Aikins M, Asare-Bediako S, Boateng R, Olympio Mensah OS, Adu-Gyamfi AA,… · 2026-09-01

    unreviewed
  7. 7
    Plasma homocysteine and Endothelin-1 dysregulation: Insights into retinal endothelial dysfunction.

    Msa M. · 2026-06-12

    unreviewed
  8. 8
    MicroRNA expression profiles in abdominal aortic aneurysms: A systematic review of potential diagnostic and prognostic biomarkers.

    Eini P, Eini P, Serpoush H, Rezayee M, Tremblay J. · 2026-05-07

    open access unreviewed
  9. 9
    Comparative Analysis of Treatment With Folate Forms in Clinical Practice.

    Skavinska O, Rossokha Z, Stefanyshyn V, Hrebeniuk O, Fishchuk L, Quadros EV, Gorovenko N. · 2026-09-01

    unreviewed
  10. 10
    Sex-Specific Associations Between MTHFR, PPARG and ADRB3 Polymorphisms, Habitual Nutrient Intake and Metabolic Risk in Obesity: A Cross-Sectional Single-Centre Study.

    Lapik IA, Tarmaeva IY, Nikityuk DB. · 2026-08-04

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.