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unreviewed

MTHFR

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

One-Carbon Metabolism (Folate Cycle)

Accelerated by

S-adenosylmethionine deficiency/low methyl-group availability favors activity; FAD sufficiency

Inhibited by

S-adenosylmethionine allosterically inhibits; folate/riboflavin deficiency reduces activity

Hormonal control

Predominantly nutrient and allosteric regulation; insulin/growth signals influence one-carbon demand indirectly

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Pediatric Spinal Cord Stroke: Clinical Presentation, MRI Features, and Suspected Mechanisms.

    Acero-Garces DO, Gordon-Lipkin E, Lin DDM, Sun LR, Felling RJ, Gailloud P, Elrick MJ, Pardo CA, Chen H. · 2026-09-30

    unreviewed
  2. 2
    Mapping current evidence and knowledge gaps in gestational diabetes mellitus in Vietnam and Vietnamese diaspora: a scoping review.

    Tran CTN, Popovich DG, Lachat C, Eri R, Tran HTM, Truong T. · 2026-09-28

    open access unreviewed
  3. 3
    Homocystinuria symptomatology collected through an international patient-report data program as a source for natural history data.

    Parke B, Bartke D, Beek G, Talebizadeh Z, Chapman KA, Baker J, Thomas JA. · 2026-09-11

    open access unreviewed
  4. 4
    Analysis of <i>MTHFR</i> C677T polymorphism in elderly Iranian women from Bushehr.

    Kaviani M, Hemati H, Asadifard E, Hokmabadi M, Bidkhori M, Sharifi F, Abiri A, Ghahghaei A, Fahimfar N, Hasan… · 2026-09-16

    unreviewed
  5. 5
    A preeclampsia prediction model incorporating methylenetetrahydrofolate reductase, vitamin D receptor, and uterine artery pulsatility index.

    Xu M, Yang G, Zhong X, Jin Z, Tang M, Xiao Y, Guo Y. · 2026-09-11

    unreviewed
  6. 6
    Homocysteine, cysteine and methionine are associated with 90-day prognosis in intracerebral hemorrhage patients.

    Fang M, Xia T, Yin Y. · 2026-08-21

    open access unreviewed
  7. 7
    Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study.

    Lin L, Yu B, Wu M, Su Y, Cui Y, Li C, Zhang Z, Teng J. · 2026-08-18

    open access unreviewed
  8. 8
    Comprehensive safety assessment of novel dicholine folate vitamin.

    Jonaitis T, Ulmann M, Wiesler G, Lukasik KV. · 2026-07-15

    open access unreviewed
  9. 9
    Individualized pharmacogenomics for depressive episodes: A narrative review.

    Haddad M, Dieckmann LHJ, Hoss GRW, de Jesus Mari J, Young AH, Juruena MF. · 2026-07-13

    unreviewed
  10. 10
    Molecular epidemiology of the MTHFR C677T polymorphism and its association with type 2 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital.

    Kassahun Berie G, Dagnaw M, Indracanti M, Dejen M, Berhane N. · 2026-03-16

    cited 1× unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.