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unreviewed

BCKDH complex

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples)

Accelerated by

Dephosphorylation by BCKDH phosphatase; elevated branched-chain keto acids

Inhibited by

Phosphorylation by BCKDH kinase; product/high-energy signals

Hormonal control

Insulin promotes BCAA uptake and protein synthesis; fasting, exercise, and cortisol favor BCAA oxidation indirectly

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Lauric acid engages an O-GlcNAc-sensitive BCKDH regulatory node to modulate branched-chain amino acid oxidation in skeletal myotubes.

    Sumi K, Shioyama M, Munakata K, Takasugi S, Morifuji M, Nakamura K. · 2026-07-16

    unreviewed
  2. 2
    Distinct metabolic dependency on BCAA defines cancer stemness and malignancy in human triple-negative breast cancer.

    Matsuura K, Shinonaga R, Yamamoto M, Yamamoto Y, Chen H, Maeno A, Okuda K, Inoue H, Imotani S, Glushka J, Mik… · 2026-07-08

    unreviewed
  3. 3
    The Complex Relation of Branched-Chain Amino Acids and Inflammation in the Obesity and Diabetes Context.

    Starling-Soares B, Coelho MM, Campolina BG, Duarte CK, Maioli TU. · 2026-01-22

    cited 2× open access unreviewed
  4. 4
    Decoding the Gut–Fat–Heart Axis: From Molecular Communication Networks to Clinical Translation Strategies

    Sun Z, Shao W, Zhang H, Wang K, Liu Y, Zhou R. · 2026-06-01

    open access unreviewed
  5. 5
    Chronic attenuation of brain leptin signalling is associated with early metabolic dysfunction in lean rats.

    Pintado C, Mazuecos L, Gómez-Torres Ó, Merino B, Casanueva-Álvarez E, Rubio B, Burgos-Ramos E, Artigas-Jeróni… · 2026-05-07

    open access unreviewed
  6. 6
    Txnrd2 loss in skeletal muscle causes muscle atrophy and drives leanness and obesity resistance.

    Kiermayer C, Erdelen R, Schriever SC, Böhm R, Prehn C, Artati A, Kleinert M, Miller M, Dyar KA, Schmid RM, Pf… · 2026-04-08

    open access unreviewed
  7. 7
    Study on the Freezing Protection Effect of Melatonin on <i>Lactobacillus plantarum</i> FQR.

    Feng Y, Wu Y, Wang M, Wang R, Song L, Mei L. · 2026-05-22

    open access unreviewed
  8. 8
    Redox Imbalance in Gestational Diabetes Mellitus: Mechanistic Insights, Emerging Biomarkers, and Therapeutic Perspectives.

    Uthaiah CA, Sahu T, Singh V, Abraham J. · 2026-05-25

    open access unreviewed
  9. 9
    Plasma metabolites after 10-weeks of glucose vs fructose-sweetened beverages in subjects with overweight/obesity.

    Guirette M, Haslam DE, Ma J, Havel PJ, Stanhope KL, Ilkayeva O, Newgard CB, McKeown NM, Herman MA. · 2026-04-27

    open access unreviewed
  10. 10
    BCAT1-dependent HIF-1α stabilization is a targetable metabolic vulnerability in hepatocellular carcinoma.

    Zhang MS, Kwan KK, Tse AP, Wang G, Wei LL, Sun K, Chui NN, Lee D, Bao MH, Pang X, Wu Z, Chen Y, Wang Y, Yang … · 2026-04-29

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.