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unreviewed

BCKDH complex

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples)

Accelerated by

Dephosphorylation by BCKDH phosphatase; elevated branched-chain keto acids

Inhibited by

Phosphorylation by BCKDH kinase; product/high-energy signals

Hormonal control

Insulin promotes BCAA uptake and protein synthesis; fasting, exercise, and cortisol favor BCAA oxidation indirectly

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Branched-chain amino acids and gut microbiota: coregulation and impact on neurological function via the gut-brain axis.

    Li Q, Fan B, Xiao Y, Zhang Z, Zhao S, Liao B, Zeng J, Shan X, Ye H, Wen Y, Zhang L, Guo H, Xiao F, Zhu H. · 2026-07-14

    open access unreviewed
  2. 2
    Metabolomic biomarkers and metabolic remodelling in genetically characterised hypertrophic cardiomyopathy: a systematic review.

    Ahmad Razmy AH, Abd Latip N, Ab-Rahim S, Sheikh Abdul Kadir SH. · 2026-10-03

    open access unreviewed
  3. 3
    Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth in <i>GNAS</i> (Gα<sub>s</sub>) mutant pancreas cancer.

    Hagedorn GA, Spieser JC, Hirai N, Sato Y, Valentine J, Jiang H, Wang W, Czyzyk-Krzeska MF, Patra KC. · 2026-09-30

    open access unreviewed
  4. 4
    Human brown fat metabolism associates with systemic branched-chain amino acids homeostasis.

    U-Din M, Acosta FM, Saari T, de Mello Laaksonen VD, van der Kolk BW, Monfort-Pires M, Clemente-Postigo M, Nie… · 2026-08-26

    open access unreviewed
  5. 5
    Mitochondria-to-plasma-membrane H<sub>2</sub>O<sub>2</sub> signaling induced by branched-chain keto acid oxidation essentially stimulates insulin secretion in pancreatic β-cells.

    Klöppel E, Engstová H, Duspiva P, Tauber J, Mozheitova O, Jabůrek M, Ježek P. · 2026-07-16

    open access unreviewed
  6. 6
    Dynamic protein phosphorylation shapes mitochondrial catalysis, import, and architecture

    · 2026-09-29

    open access unreviewed
  7. 7
    The Role of Branched-Chain Amino Acids in Nutrient Allocation of the Porcine Placenta: A Review.

    Bai J, Wang Y, Li X, Li J, Wu Z, Li X, Wang K, Qiao R, Fu T, Li Y. · 2026-09-10

    open access unreviewed
  8. 8
    Divergent amino acid profiles in sarcopenic obesity versus non-obese sarcopenia: A prospective cohort study in community-dwelling older adults.

    Zhang T, Wu Y, Li S, Leung J, Kwok T. · 2026-09-11

    open access unreviewed
  9. 9
    Amino Acid Metabolism in Health and Disease.

    Su Z, Liu J, Deng X, Luo Y, Xue H, Wang L, Xing L, Wu T. · 2026-08-28

    open access unreviewed
  10. 10
    Treating a Disorder Caused by an Overactive Enzyme: BCKD-Kinase Deficiency.

    Ribeiro-Constante J, Tangeraas T, García-Cazorla A. · 2026-09-01

    cited 1× unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.