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unreviewed

Hepatic glutaminase

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Oxidative Deamination

Accelerated by

Glutamine availability; chronic high-protein intake/acidosis can increase expression

Inhibited by

Product accumulation; reduced demand for ammonia disposal

Hormonal control

Glucagon can support hepatic ureagenic flux; regulation is largely transcriptional and substrate-driven

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism.

    Mao Y, Xia Z, Pan X, Xia W, Jiang P. · 2026-04-17

    cited 2× unreviewed
  2. 2
    A Global Perspective on Metabolic Dysfunction-Associated Steatotic Liver Disease: From Molecular Mechanisms to Therapeutic Strategy Innovation.

    Qiu Y, Laguna JC, Alegret M, Vilà L. · 2026-02-19

    cited 1× open access unreviewed
  3. 3
    Increased urea nitrogen salvaging by a remodeled gut microbiota helps nonhibernating pikas maintain protein homeostasis during winter.

    Shi F, Zou D, Zhang L, Guo N, Yu J, Degen AA, Tang X, Ren S, Ru Y, Zheng S, Zhang Y, Wang D. · 2025-10-16

    cited 1× open access unreviewed
  4. 4
    Short-term Physical Activity Reduces Metabolic-associated Steatohepatitis by Promoting the Degradation of Branched-chain Amino Acids in Skeletal Muscle.

    Gao M, Li J, Zhang Y, Huang J, Chen J, Liao D, He S, Bi Q, Ji L, Du Y. · 2025-05-30

    cited 1× open access unreviewed
  5. 5
    Preclinical atherosclerosis and prediabetes: a cross-sectional metabolic assessment in apparently healthy population.

    Zieleniewska N, Jamiołkowski J, Kondraciuk M, Ciborowski M, Ptaszyńska K, Chlabicz M, Dubatówka M, Roszkowska… · 2025-07-10

    cited 3× open access unreviewed
  6. 6
    Islet hormones at the intersection of glucose and amino acid metabolism.

    White PJ, Wewer Albrechtsen NJ, Campbell JE. · 2025-03-07

    cited 8× unreviewed
  7. 7
    Loss of hepatic autophagy induces α-cell proliferation through impaired glutamine-dependent gluconeogenesis.

    Velasco-Silva JN, Wilkerson JL, Ramos D, Low HK, Bowman F, Evason KJ, Boudina S, Holland WL, Ducker GS. · 2025-05-01

    cited 1× open access unreviewed
  8. 8
    Hyperammonemia induces programmed liver cell death.

    Kerbert AJC, Engelmann C, Habtesion A, Kumar P, Hassan M, Qi T, Volkert I, Otto T, Hall A, Khetan VU, Olde Da… · 2025-03-07

    cited 17× open access unreviewed
  9. 9
    Rat Model of Endogenous and Exogenous Hyperammonaemia Induced by Different Diets.

    Donaldson J, Jacek T, Wychowański P, Zaworski K, Szkopek D, Woliński J, Grujic D, Pierzynowski S, Pierzynowsk… · 2025-02-20

    cited 1× open access unreviewed
  10. 10
    Macrophage Polarization in the Tumor Microenvironment of Hepatocellular Carcinoma: From Mechanistic Insights to Translational Therapies.

    Fu X, Pang M, Wang Z, Wang H. · 2025-01-01

    cited 4× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.