ALT (GPT)
What it does, reaction by reaction
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Transamination
Substrate availability; increased hepatic amino-acid flux
No dominant acute allosteric inhibitor
Insulin promotes amino-acid uptake and protein synthesis; glucagon/cortisol increase hepatic amino-acid catabolic capacity indirectly during fasting or stress
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Evaluation of subacute toxicity of highly bioavailable curcuRouge® formulation by a repeated dose 28-day oral exposure toxicology study in sprague dawley rats with safety assessment.
Kapoor MP, Musumi K, Katsuura Y, Aoyama H, Kochizawa M, Tanigaki K, Kishimoto A, Hashimoto T. · 2026-08-27
open access unreviewed -
2
A 12-week, double-blind, quasi-randomized, placebo-controlled study to evaluate the efficacy and safety of <i>Coleus forskohlii</i> (Forcslim) on body weight loss.
Channangihalli Thimmegowda S, Hussain Mirza FH, Venkataraman R, Nagarajaiah RB. · 2026-09-01
open access unreviewed -
3
Carryover effects of dietary arginine on productive performance and blood biochemistry in Japanese quail (<i>Coturnix japonica</i>).
Gashew M, Reda GK, Knop R, Szabó C, Lendvai ÁZ, Czeglédi L. · 2026-07-19
open access unreviewed -
4
Non-absorbable antibiotics worsen alcohol-associated liver disease in gastric acid-suppressed mice.
Raya Tonetti F, Han H, Fondevila MF, Wei W, Özdirik B, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Lang … · 2026-07-08
open access unreviewed -
5
A dual-gene-deleted ASFV Lv17/WB/Rie1-ΔCD candidate administered orally to wild boar confers DIVA-compatible protection against virulent challenge.
Barasona JA, Kosowska A, González-García G, Díaz-Frutos M, Franzoni G, Nicolussi P, Porras N, Sánchez-Segovia… · 2026-03-26
open access unreviewed -
6
[Massive/mass-forming ductular reaction (MDR) in angioinvasive hepatocellular carcinoma : Pathogenesis and differential diagnoses of a hepatic pseudotumor].
Fischer AK, Büttner R, Persigehl T, Fischer HP. · 2026-06-23
open access unreviewed -
7
Dose-Dependent Hepatotoxicity of Zinc Oxide Nanoparticles in Rats: Oxidative Stress, Apoptosis, and Dysregulation of Hepatic miR-122, miR-34a, and miR-21.
Hatem RM. · 2026-09-10
open access unreviewed -
8
Comparative Evaluation of the Functional and Immunomodulatory Properties of Raw and Spray-Dried Donkey Milk.
Plotuna AM, Hotea I, Imre K, Herman V, Nichita I, Popa I, Pop M, Tîrziu E. · 2026-09-15
open access unreviewed -
9
Palmatine-Intercalated Montmorillonite Improves Intestinal Health and Attenuates Systemic Inflammation in ETEC-Challenged Piglets.
Gan L, Zhao Y, Li S, Sheng Y, Zhao D, Yuan Y, Qiao H, Wang P, Duan E, Liu T, Wang J. · 2026-09-11
open access unreviewed -
10
CRISPR/dCas9-induced upregulation of endogenous apolipoprotein A1 and paraoxonase 1 genes reduces the aortic lipid deposits in apoE<sup>-/-</sup> mice.
Toma L, Barbălată T, Hărătău JIC, Sanda GM, Fuior EV, Fenyo IM, Niculescu LŞ, Dăian LM, Sasson S, Sima AV, St… · 2026-09-18
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.