unreviewed
LDL receptor (LDLR)
0 reactions · 0 pathways
What it does, reaction by reaction
0 reactions
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
1 entries
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL)
Accelerated by
SREBP-2 when hepatocyte cholesterol is low; receptor recycling
Inhibited by
Intracellular cholesterol; PCSK9-mediated degradation
Hormonal control
Insulin can increase expression; statin-mediated cholesterol depletion strongly increases LDLR through SREBP-2
Recent literature
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