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unreviewed

TCA-cycle dehydrogenases

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Ketolysis (Ketone Body Utilization)

Accelerated by

ADP, Ca2+ (muscle), NAD+

Inhibited by

ATP, NADH, citrate/succinyl-CoA at relevant steps

Hormonal control

Insulin promotes carbohydrate oxidation; fasting increases ketone supply, while use depends on tissue energy demand

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Targeting Mitochondria in Aging-Related Diseases: Therapeutic Potential and Obstacles.

    Xiang Z, Chen Y, Liu X, Lu H, Yang Y, Xing L, Zhang Y, Lang C, Zhang S, Zhao S, Hong Y, Bai J, Qiao Y. · 2026-06-04

    open access unreviewed
  2. 2
    Autophagy-Apoptosis Crosstalk in Cancer: Mechanisms, Signaling Pathways, and Therapeutic Targeting.

    Kakkar D, Saxena S, Dhawan U, Dosi N, Khanna C, Paul S. · 2026-05-12

    open access unreviewed
  3. 3
    Re-evaluating the rationale for targeting oxidative phosphorylation in acute myeloid leukemia.

    Chrest BR, Fisher-Wellman KH. · 2026-05-01

    unreviewed
  4. 4
    Biallelic MCUR1 nonsense mutation associated with vacuolar myopathy and altered mitochondrial calcium signaling.

    Haschke AM, von Renesse A, Graceffo E, Morales-Gonzalez S, Prigione A, Hübner C, Stenzel W, Schuelke M. · 2026-05-05

    open access unreviewed
  5. 5
    Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle.

    Xie A, Brunner JS, Chakraborty S, Montero AM, Bridgeman AE, Paras KI, Cui R, Fagoaga-Eugui M, Komza M, Arnold… · 2026-02-27

    cited 4× open access unreviewed
  6. 6
    ROS-scavenging nanoparticles loaded with tectorigenin protect against acetaminophen-induced hepatotoxicity by interrupting the calcium/ROS-mediated pathogenic endoplasmic reticulum-Mitochondrial signaling cascade.

    Zhang Y, Jin Z, Xu L, Zhong Z, Wang X, Gao C, Li L. · 2025-12-13

    cited 2× open access unreviewed
  7. 7
    Targeting Mitochondrial Vulnerabilities in Chronic Myeloid Leukemia: From Pathobiology to Novel Therapeutic Opportunities.

    Caprino F, Valentino I, Bruzzese A, Ganino L, Mesuraca M, Citraro R, Gentile M, Gallo Cantafio ME, Amodio N. · 2026-03-18

    cited 1× open access unreviewed
  8. 8
    STIM1-containing contact sites promote direct calcium flux from the endoplasmic reticulum to mitochondria.

    Orantos-Aguilera Y, Sanchez-Lopez I, Pascual-Caro C, Gómez-Suaga P, Area-Gomez E, Pozo-Guisado E, Montesinos … · 2026-02-11

    cited 1× open access unreviewed
  9. 9
    Developmentally specific physiological and metabolic responses support drought resilience in switchgrass and constrain biofuel yield.

    Basyal B, Li X, Pargulski VJ, Fu X, Nightingale NM, Overmyer KA, Coon JJ, Zhang Y, Benucci GMN, Last RL, Sato… · 2026-03-01

    open access unreviewed
  10. 10
    Human lncRNA <i>RMRP</i> interacts with DEAD-box helicases and modulates mitochondrial function.

    Pereira HS, Luddu J, Veerareddygari GR, Sanghvi SK, Patel PB, Robinson ZE, Siddiqui MQ, Singh H, Patel TR. · 2026-02-20

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.