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unreviewed

SCOT/OXCT1

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Ketolysis (Ketone Body Utilization)

Accelerated by

Acetoacetate availability; tissue mitochondrial oxidative capacity

Inhibited by

No dominant acute allosteric inhibitor; absent in liver by tissue-specific expression

Hormonal control

Primarily controlled by substrate availability and tissue expression rather than acute hormonal regulation

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    A Mitochondrial Plasma Proteomic Signature Identifies Metastatic Chromophobe Renal Cell Carcinoma.

    Steiner C, Han T, Safi S, Bzeih W, Mansour H, Saad E, Williams JF, Hirsch MS, Giri VK, Ascione L, Elon Y, Dic… · 2026-03-23

    open access unreviewed
  2. 2
    The value of targeting ketone body metabolism in inflammatory and autoimmune diseases.

    Gong Y, Wei Y, Liu Y, Du T. · 2026-03-04

    open access unreviewed
  3. 3
    Brain Ketone Bodies in Health, Evolution and Disease.

    Bougnères P. · 2026-02-23

    open access unreviewed
  4. 4
    RNAi-based screen for pigmentation in <i>Drosophila melanogaster</i> reveals regulators of brain dopamine and sleep.

    Deal SL, Bei D, Gibson SB, Delgado-Seo H, Fujita Y, Wilwayco K, Seto ES, Sehgal A, Yamamoto S. · 2025-12-11

    cited 2× open access unreviewed
  5. 5
    The Heart Has Intrinsic Ketogenic Capacity that Mediates NAD<sup>+</sup> Therapy in HFpEF.

    Koay YC, McIntosh B, Ng YH, Cao Y, Wang XS, Han Y, Tomita S, Bai AY, Hunter B, Misra A, Loughrey CM, Bannon P… · 2025-04-11

    cited 14× open access unreviewed
  6. 6
    Partial Regulation of Ketone Metabolism by Hypoxia in H9C2 Cardiomyocytes.

    Chen LZ, Chen HQ, Zhang XY, Ling S, Xu JW. · 2025-02-20

    unreviewed
  7. 7
    A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart.

    Jacobs B, Derese I, Derde S, Vander Perre S, Pauwels L, Van den Berghe G, Gunst J, Langouche L. · 2025-01-17

    cited 3× open access unreviewed
  8. 8
    Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes.

    Shichkova P, Coggan JS, Markram H, Keller D. · 2024-10-17

    cited 19× open access unreviewed
  9. 9
    Bioinformatics and systems biology approaches to identify potential common pathogeneses for sarcopenia and osteoarthritis.

    Yang J, Zhong J, Du Y, Wang Z, Jiang L, Li Z, Liu Y. · 2024-06-18

    cited 2× open access unreviewed
  10. 10
    Protein succinylation: regulating metabolism and beyond.

    Hou X, Chen Y, Li X, Gu X, Dong W, Shi J, Ji S. · 2024-02-06

    cited 20× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.