Skip to content
MS
Sign in
unreviewed

SCOT/OXCT1

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Ketolysis (Ketone Body Utilization)

Accelerated by

Acetoacetate availability; tissue mitochondrial oxidative capacity

Inhibited by

No dominant acute allosteric inhibitor; absent in liver by tissue-specific expression

Hormonal control

Primarily controlled by substrate availability and tissue expression rather than acute hormonal regulation

Recent literature

Refresh

Europe PMC · fetched just now · sorted by publication date

  1. 1
    Murine metabolic HFpEF is associated with altered mitochondrial substrate handling and S-nitrosylation remodeling.

    Li H, Cui H, Wang D, Leuschner F, Heineke J, Hu J, Bibli SI. · 2026-08-12

    open access unreviewed
  2. 2
    Ketogenic diet as a systems-level immunometabolic sensitization strategy in cancer therapy: integrating metabolism, immune reprogramming, microbiome dynamics, and epigenetic regulation.

    Mannan MS, Khan MW, Haseeb Khan MA, Javed A, Hussain SM, Adil H. · 2026-09-25

    open access unreviewed
  3. 3
    Ketone metabolism in heart failure with preserved ejection fraction: Fuel, signaling, and therapeutic opportunities.

    Yao Y, Gu Z, Hu J, Zhu W, Lin Q. · 2026-09-21

    unreviewed
  4. 4
    Neuronal ketone body utilization couples exercise and time-restricted feeding to cognitive enhancement.

    Salathe SF, Kugler BA, Franczak E, Davis XC, Boakye FB, Allen J, Fulghum KL, Queathem ED, Morris EM, Puchalsk… · 2026-07-16

    open access unreviewed
  5. 5
    A Mitochondrial Plasma Proteomic Signature Identifies Metastatic Chromophobe Renal Cell Carcinoma.

    Steiner C, Han T, Safi S, Bzeih W, Mansour H, Saad E, Williams JF, Hirsch MS, Giri VK, Ascione L, Elon Y, Dic… · 2026-03-23

    open access unreviewed
  6. 6
    The value of targeting ketone body metabolism in inflammatory and autoimmune diseases.

    Gong Y, Wei Y, Liu Y, Du T. · 2026-03-04

    open access unreviewed
  7. 7
    Brain Ketone Bodies in Health, Evolution and Disease.

    Bougnères P. · 2026-02-23

    cited 1× open access unreviewed
  8. 8
    RNAi-based screen for pigmentation in <i>Drosophila melanogaster</i> reveals regulators of brain dopamine and sleep.

    Deal SL, Bei D, Gibson SB, Delgado-Seo H, Fujita Y, Wilwayco K, Seto ES, Sehgal A, Yamamoto S. · 2025-12-11

    cited 5× open access unreviewed
  9. 9
    The Heart Has Intrinsic Ketogenic Capacity that Mediates NAD<sup>+</sup> Therapy in HFpEF.

    Koay YC, McIntosh B, Ng YH, Cao Y, Wang XS, Han Y, Tomita S, Bai AY, Hunter B, Misra A, Loughrey CM, Bannon P… · 2025-04-11

    cited 14× open access unreviewed
  10. 10
    Partial Regulation of Ketone Metabolism by Hypoxia in H9C2 Cardiomyocytes.

    Chen LZ, Chen HQ, Zhang XY, Ling S, Xu JW. · 2025-02-20

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.