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unreviewed

D-β-hydroxybutyrate dehydrogenase

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

2 entries

Ketogenesis

Accelerated by

High mitochondrial NADH/NAD+ ratio

Inhibited by

Lower NADH/NAD+ ratio

Hormonal control

Regulated primarily by redox state, not direct phosphorylation

Ketolysis (Ketone Body Utilization)

Accelerated by

NAD+ availability in the consuming tissue

Inhibited by

High NADH/NAD+ ratio

Hormonal control

Indirectly governed by mitochondrial redox state

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Symptom impact and safety of ketogenic therapy in adults with anorexia nervosa: a feasibility trial.

    Frank GKW, Scolnick B, Beckwith C, Shott ME, Kilty S, Swindle S, Lutter M, Rho JM. · 2026-06-03

    cited 2× open access unreviewed
  2. 2
    Quantifying endogenous and tracer-derived ketone bodies using a dual-label UHPLC-MS/MS method.

    Adámez-Rodríguez S, Queathem ED, Hayir A, Marina ML, Castro-Puyana M, Puchalska P. · 2025-09-30

    cited 2× unreviewed
  3. 3
    Metabolic Checkpoints in CD8<sup>+</sup> T Cells within the Tumor Microenvironment: A Comprehensive Review and Emerging Insights.

    Ai J, Du Y, Xue Q, Peng W, Zhou Q. · 2026-01-22

    cited 4× open access unreviewed
  4. 4
    β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review).

    Ding X, Wu J, Wang L, Li K, Gao H, Wu M, Zhang Q, Han R, Wang W, Xiao W. · 2025-11-07

    cited 2× open access unreviewed
  5. 5
    Immunocytes Play a Crucial Role as Mediators in the Protective Effects of D-β-Hydroxybutyrate Dehydrogenase 1 against Type 2 Diabetes Mellitus: A Mendelian Randomization Study

    Liu YY, Zhang YY, Wan Q. · 2026-01-01

    cited 1× open access unreviewed
  6. 6
    Manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) represses sulfide:quinone oxidoreductase expression and targets the sulfido-redox system in glioblastoma models.

    Malard E, Bernay B, Toutain J, Ballesta S, Lévêque M, Pontin J, Valable S, Bernaudin M, Chatre L. · 2025-09-18

    cited 2× open access unreviewed
  7. 7
    Diet as a Modulator of Gut Microbiota May Reduce Alzheimer's Disease Risk.

    Ochocińska AM, Podstawka I, Kępka A, Waszkiewicz N. · 2025-09-24

    cited 5× open access unreviewed
  8. 8
    Role of Liver-Derived Ketones, Hepatokines, and Metabolites in the Regulation of Renal Function.

    Arthur G, Adenawoola MI, Wahba S, Montgomery BS, Stec DE. · 2025-07-21

    cited 4× open access unreviewed
  9. 9
    Ketone Bodies in Cardiovascular Disease: The Vasculature as a Therapeutic Target.

    Challa AA, Hill BG, Nystoriak MA, Gouwens KR, Kalra DK. · 2025-07-17

    cited 4× open access unreviewed
  10. 10
    Aerobic Exercise Delays Age-Related Sarcopenia in Mice via Alleviating Imbalance in Mitochondrial Quality Control.

    Zhu D, Wang L, Gao H, Wang Z, Li K, Ma X, Zhao L, Xiao W. · 2025-07-11

    cited 2× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.