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unreviewed

CPT-1

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

2 entries

Beta-Oxidation of Fatty Acids

Accelerated by

Low malonyl-CoA; increased fatty-acyl-CoA supply

Inhibited by

Malonyl-CoA (potent allosteric inhibitor)

Hormonal control

Glucagon/epinephrine favor oxidation indirectly by lowering ACC activity and malonyl-CoA; insulin raises malonyl-CoA and restrains CPT-1

Ketogenesis

Accelerated by

Low malonyl-CoA, fatty-acyl-CoA availability

Inhibited by

Malonyl-CoA

Hormonal control

Glucagon/epinephrine lower malonyl-CoA and increase fatty-acid entry; insulin opposes this

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    A logic-gated nanoplatform spatiotemporally orchestrates immunometabolic reprogramming and osteogenesis for diabetic periodontal regeneration.

    Jiang Y, Liu S, Li X, Han L, Liu H, Li M. · 2026-09-04

    open access unreviewed
  2. 2
    Danshen-Chuanxiong alleviates cerebral ischemia by regulating carnitine metabolism and angiogenesis via activating CPT1/HIF-1α signaling axis.

    Pang HQ, Zhang XH, Zhang JL, Zhang L, Zhao YJ, Yan YP, Lu X, Yan BC. · 2026-07-10

    unreviewed
  3. 3
    Low-dose l-carnitine supplementation attenuates hepatic lipid accumulation in chow-fed mice: Insights from integrated multi-omics analysis.

    Zhang Z, Ding B, Zhang L, Zhang L, Huang Y. · 2026-09-10

    open access unreviewed
  4. 4
    Hepatocyte SLC31A1-dependent copper accumulation contributes to hepatic glucose and lipid metabolic disturbances through AMPKα1 inactivation.

    Cheng YQ, Wei M, Yang L, Zhuang YY, Lu QB. · 2026-09-11

    open access unreviewed
  5. 5
    Phloretin as a functional feed bioactive in livestock: Biological role, biosynthesis, and practical applications.

    Areb E, Zhu Q, Han L, Pan C, Li W, Lan X. · 2026-07-25

    open access unreviewed
  6. 6
    Effectiveness and moderators of PE and CPT in adult PTSD treatment: a systematic review and meta-analysis.

    Xu B, Cai Q, Basha SAJ, Anderson S, Vannini MB, Malek N, Blais RK. · 2026-09-09

    open access unreviewed
  7. 7
    <i>Bacteroides cellulosilyticus</i>-derived 2-hydroxyphenylacetic acid rectifies hepatic lipid homeostasis in MASLD by targeting the PPARγ-CD36 axis.

    Chen K, Yang Z, Peng J, Liu C, Yu Y, Cai X, Liu B, Li S, Chen T, Jung S, Tian Y, Xu Q, Rao X, Wu Z, Wang H, D… · 2026-09-01

    open access unreviewed
  8. 8
    Multi-omics characterization of glucose-lipid metabolic remodeling associated with Gymnema sylvestre (Retz.) R.Br. ex Sm. treatment in a type 2 diabetic mouse model.

    Zeng Z, Liu Y, Xiao G, Jia C, Wu M, Li Y, Jiang J, Zhang J, Xu A, Bi X. · 2026-06-20

    unreviewed
  9. 9
    Soil-derived microbiota induces T regulatory cells and protect against mouse colitis, metabolic disease, and sepsis.

    Szurek EA, Ngo VL, Abo H, Cebula A, Chassaing B, Howard RA, Hart M, Hori S, Weaver CT, Gewirtz AT, Ignatowicz… · 2026-05-24

    cited 1× open access unreviewed
  10. 10
    Alcohol consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): understanding the gut-liver crosstalk for clinical translation.

    Benedé-Ubieto R, Estévez-Vázquez O, Acar R, Leal-Lassalle H, Gutierrez AH, Redondo-Urzainqui A, Iborra S, Odi… · 2026-02-21

    cited 4× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.